2012 Fiscal Year Final Research Report
Identification of therapeutic target molecules againstatrial fibrillation: Use of the canine persistent atrial fibrillation model
| Project/Area Number |
22590237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心血管 / 血液 / 心房細動 |
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| Research Abstract |
The chronic persistent atrial fibrillation model was developedfirst. The complete atrioventricular block was produced to the beagle, the left atrium was equipped with the pacing electrode, and electric stimulus generating equipment was embedded at the right buttock subcutaneous part. Chronic persistent atrial fibrillation was induced by performing an electric stimulus (600 bpm) of an atrium for four weeks. Next, the existing drugs (pilsicainide, disopyramide, aprindine, cibenzoline), an I_Kurblocking agent (AVE0118), and oseltamivir were evaluated in this model. It became clear that oseltamivir has more potent antiarrhythmic effect than the existing anti-atrial fibrillation drugs.
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