2012 Fiscal Year Final Research Report
Study of regeneration treatment with cobalt chloride-induced retinal degeneration model
| Project/Area Number |
22590239
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARA Akira 岐阜大学, 大学院・医学系研究科, 教授 (10242728)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 再生医学 / 中枢神経 / 網膜 / 神経障害 / ES細胞 / コバルトクロライド / NMDA / 奇形種発現 |
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| Research Abstract |
The ultimate goal of this study is treatment of retinal degeneration by regeneration. As a pre-stage, we constructed suitable regeneration condition using retinal degeneration model treating with CoCl2or NMDA. The results indicate hypoxia condition might be good for neuronal differentiation, and herpes simplex virus-thymidine kinase transgene transfected ES cells is good for prevention of expression of teratoma.
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