2013 Fiscal Year Final Research Report
Elucidation of cellular network for plastic change of vascular smooth muscle cell.
| Project/Area Number |
22590240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OOI Atsushi 三重大学, 大学院生物資源学研究科, 准教 (70203693)
NAKAMURA Akio 群馬大学, 大学院医学系研究科, 講師 (30282388)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 血管平滑筋 / 動脈硬化症 / 細胞骨格 / シグナル伝達 / 形質変換 |
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| Research Abstract |
Vascular smooth muscle cell composing wall of blood vessel contributes the control of blood pressure, by stretching or contracting the cell body. Life style related illness is often originated by atherosclerosis. In such vessel, normal contractile smooth muscle cell changes its property and differentiates into synthetic phenotype. To know the mechanism of the phenotypic change of the cell, we investigated expression level of several genes, and we found that several genes including T-plastin were related to the beginning of atherosclerosis.
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