2012 Fiscal Year Final Research Report
The renal protective effects of nitrite salts in diabetic nephropathy model rats.
| Project/Area Number |
22590241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TSUCHIYA Koichiro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (70301314)
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| Co-Investigator(Kenkyū-buntansha) |
TOMITA Shuhei 鳥取大学, 医学部, 教授 (00263898)
ISHIZAWA Keisuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60398013)
HAMANO Shuichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60530392)
TAMAKI Toshiaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (80179879)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腎臓 / 亜硝酸 |
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| Research Abstract |
Nitric oxide (NO) plays multipotent effects in many kinds of physiological processes. NO is generated by NO synthase (NOS), and disorders in the NOS is known to be related to diabetic nephropathy. Therefore, it has been believed that the production of NO from nitrite by non-enzymatic or enzymatic reduction responsible for the renoprotective effects of it. However, in this study, we found that nitrite suppress intracellular ATP level, then activates 5’AMP-activated protein kinase(AMPK), and following endotherial NOS activation. The activation of AMPK-eNOS pathway in endotherial cells is supposed to play a significant renal protective role in the nitrite action in addition to the NOS-independent NO production by nitrite.
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