2012 Fiscal Year Final Research Report
Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease
| Project/Area Number |
22590250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KONDO Kazunao 藤田保健衛生大学, 医学部, 教授 (90270983)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生理活性物質 / テトラヒドロビオプテリン |
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| Research Abstract |
Biopterin content in the brains of Pts-/-DPS mice was fewer than that of wild type mice. The amount of dopamine in the brains of wild type mice increased according to the date after birth, however, that of Pts-/-DPS mice did not. Serotonin content in the brains of Pts-/- mice decreased by P7. The amount of tyrosine hydroxylase protein in the brains of wild type mice increased according to the date after birth. On the contrary, that in the Pts-/-DPS brains did not. Phenylalanine content in the brains of Pts-/-DPS mice dramatically increased between P0 and P7.
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Research Products
(21 results)
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[Journal Article] Recovery of neurogenic amines in phenylketonuria micefollowing liver-targeted gene therapy.2012
Author(s)
Hiroya Yagi, Sho Sanechika, Sho Shimaguchi, Hiroshi Ichinose, Chiho Sumi-Ichinose, Hiroaki Mizukami, Masashi Urabe, Hiromi Hamada, Hiroyuki Yoshikawa,Keiya Ozawa, Akihiro Kume.
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Journal Title
Neuroreport
Volume: 23(1)
Pages: 30-34
Peer Reviewed
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[Presentation] Disturbance in the biosynthesis of monoamines andPTSD-like phenotype in the dihydrpterinr reductase-deficient mice.2012
Author(s)
Hiroshi Ichinose, Yusuke Sudo, ShoSanechika, Koichi Tanda, Kenzo Takao, Yoshitaka Hara, Shun-ichiro Honda, Sho Shimaguchi, Masayo Kojima, ChihoSumi-Ichinose, Takahide Nomura, KazunaoKondo, Tsuyoshi Miyakawa
Organizer
第35回日本神経科学大会
Place of Presentation
名古屋
Year and Date
20120918-21
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[Presentation] Chiho Sumi-Ichinose, Takahide Nomura, Daniel Metzger.2012
Author(s)
Hiroshi Ichinose, Hirofumi Tokuoka,Shin-ichi Muramatsu
Organizer
Regulation of dopamine contein in the striatum after ablation of the tyrosine hydroxylase gene in the substantia nigra. 10th International Catecholamine Symposium.
Place of Presentation
Asilomar,USA
Year and Date
20120909-13
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[Presentation] Characterization of dihydropteridine reductase knockout mice15th2012
Author(s)
Hiroshi Ichinose, Sho Sanechika, Yoshitaka Hara, Yusuke Sudo, Feng Xu, Shun-ichiro Honda, Sho Shimaguchi, Shigeki Matsuki, Mieko Horiguchi, MasayoKojima, Takahide Nomura, Kazunao Kondo, Chiho Sumi-Ichinose.
Organizer
International Symposium onPteridines and Folates
Place of Presentation
Antalya Turkey
Year and Date
20120509-13
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