2012 Fiscal Year Final Research Report
Inhibition of the morphine-induced tolerance and psychic dependence: Relation to vasopressin receptors
| Project/Area Number |
22590252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
TAKANO Yukio 福岡大学, 薬学部, 教授 (50113246)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Kenji 福岡大学, 薬学部, 助教 (60140761)
TAKASAKI Koutaro 福岡大学, 薬学部, 助教 (70461506)
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| Project Period (FY) |
2010 – 2012
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| Keywords | モルヒネの耐性 / バソプレシン受容体 / 脊髄 / 痛み / サイトカイン |
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| Research Abstract |
Pain control is very important, because, for instance, even now 20 million people suffer from neuropathic pain. Although many basic science and clinical researchers have made efforts to control pain, the mechanism of pain is unfortunately not fully understood.Even today, morphine, a prototypical opioid, is useful medicine to relieve severe pain. However, repeated or continuous use of morphine and other opioids are associated with a potential risk of analgesic tolerance, which requires an increase in the dose to maintain the same efficacy. In this research, therefore, we examined (1) the mechanisms of neuropathic pain and (2) the tolerance development to morphineThe findings in this project may cast new light on clinical use of morphine in the future.
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Research Products
(19 results)
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[Journal Article] Long-Term Culture of Astrocytes Attenuates the Readily Releasable Pool of Synaptic Vesicles2012
Author(s)
Kawano H, Katsurabayashi S, Kakazu Y,Yamashita Y, Kubo N, Kubo M, Okuda H, Takasaki K, Kubota K, Mishima K, Fujiwara M, Harata N and Iwasaki K.
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Journal Title
PLoSONE.
Volume: 7
Pages: e48034
Peer Reviewed
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[Journal Article] Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia2011
Author(s)
Takasaki K, Uchida K, Fujikawa R, NogamiA, Nakamura K, Kawasaki C, Yamaguchi K, Morita M, Morishita K, Kubota K,Katsurabayashi S, Mishima K, Fujiwara M, Iwasaki K
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Journal Title
J Pharmacol Sci
Volume: 116
Pages: 232-237
Peer Reviewed
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