2012 Fiscal Year Final Research Report
Physiological function of novel factor related to hepatic fat accumulation
| Project/Area Number |
22590253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKIGUCHI Soichi 独立行政法人国立病院機構, 九州がんセン ター臨床研究部, 室長 (00280793)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 転写 |
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| Research Abstract |
Hepatic PPARgamma-Dependent 1(hpd1) gene was isolated as high level in fatty liver of leptin-deficient (ob/ob) mouse and as unknown function. The expression of hpd1 gene is at markedly lower levels in ob/ob livers lacking PPARgamma. The present study shows that a functional PPAR response element (PPRE), located in promoter region of hpd1, directly interacts with PPARgamma. The hpd1 gene was highly expressed in not only fatty liver but also white and brown adipose tissues. To assess subcellular localization of hpd1 protein, 3T3-L1 adipocytes were fractionated by differential centrifugation. The result showed that the hpd1 protein is exclusively detected in the microsomal fraction. However, the exact subcellular localization of hpd1 protein remains to be clarified. Taken together, these results indicate that hpd1 gene is a direct target gene of PPARgamma. The gene product may be associated with fat accumulation in liver or adipose tissues.
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[Journal Article] Hepatic peroxisome proliferator-activatedreceptor-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals.2011
Author(s)
K Uno, T Yamada, Y Ishigaki, J Imai, Y Hasegawa, J Gao, K Kaneko, K Matsusue, T Yamazaki, Y Oka, and H Katagiri.
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Journal Title
European Heart Journal
Volume: 33
Pages: 1279-1289
DOI
Peer Reviewed
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