2012 Fiscal Year Final Research Report
Dysfunction of brain pericytes contributes to development of type2 diabetes mellitus
| Project/Area Number |
22590255
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DOHGU Shinya 福岡大学, 薬学部, 准教授 (60399186)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳ペリサイト / 2型糖尿病 / 血液脳関門 |
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| Research Abstract |
In this study, we hypothesized that brain pericytes are a glucose sensing cell and respond to high glucose levels to impair the blood-brain barrier (BBB) and hypothalamic neuron. Our major findings are as follows; (1) BBB function was impaired in high-fat diet-induced obese mouse with hyperglycemia, (2) High glucose levels enhanced TNF-a-induced release of MMP-9 from cultured brain pericytes, (3) Brain pericytes regulate insulin sensitivity and anorexic signaling in the hypothalamic neuron by releasing soluble factors. These results suggest that changes in brain pericyte-derived soluble factors under hyperglycemia contribute to the impairment of BBB and the insulin resistance in hypothalamic neurons.
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Research Products
(50 results)
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[Journal Article] In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.2013
Author(s)
Takata F, Dohgu S, Yamauchi A, Matsumoto J, Machida T, Fujishita K, Shibata K, Shinozaki Y, Sato K, Kataoka Y, Koizumi S.
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Journal Title
PLoS One
Volume: 8(1)
Pages: e55166
DOI
Peer Reviewed
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[Journal Article] Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro2011
Author(s)
Takata F, Dohgu S, Matsumoto J, Takahashi H, Machida T, Wakigawa T, Harada E, Miyaji H, Koga M, Nishioku T, Yamauchi A, Kataoka Y.
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Journal Title
J Neuroinflammation.
Volume: 8
Pages: 106
DOI
Peer Reviewed
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[Presentation] NADPH oxidase-derived reactive oxygen species (ROS) facilitate TNF-alpha-induced up-regulation of MMP-9 production in the brain pericytes through Akt activation2010
Author(s)
Takata F, Dohgu S, Matsumoto J, Machida T, Furuno T, Ichiki N, Kaneshima S, Miyaji H, Tao S, Shuto H, Yamauchi A, Kataoka Y.
Organizer
13th International Blood-Brain Barrier Symposium
Place of Presentation
University Hospital Zurich(スイス)
Year and Date
2010-09-02
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