2013 Fiscal Year Final Research Report
Biological analyses of scavenger receptor CL-P1 which is a host defense factor
| Project/Area Number |
22590259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2010-10-20 – 2013-03-31
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| Keywords | 発生・分化 / コレクチン / スカベンジャー受容体 / 血管内皮細胞 / ノックアウトマウス |
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| Research Abstract |
I have been working for the elucidation of the role in the biological and developmental processes of CL-P1. Since the CL-P1 gene knockout mice are embryonic lethal, I examined the lethal time, it was clarified that it is pre-implantation. I have studied a function of CL-P1 after the fertilization using the transgenic mouse which developed GFP by the promoter of the CL-P1 gene, but I was able to confirm the expression from immediately after fertilization, but it was not possible to clarify whether play what function. And creating conditional knockout mice in order to analyze the role in vivo, it was examined, but did not provide a new finding at the present stage. I continue examining it and would like to try for the elucidation of the biological CL-P1 in future.
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[Journal Article] The induction of human CL-P1 expression in hypoxia/ reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment2011
Author(s)
Koyama S, Ohtani K, Fukuzawa J, Yao N, Fukuda M, Jang SJ, Hasebe N, Kikuchi K, Itabe H, Yoshida I, Suzuki Y, Wakamiya N
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Journal Title
Biochim Biophys Acta
Volume: Vol. 1810
Pages: 836-842
DOI
Peer Reviewed
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