2012 Fiscal Year Final Research Report
Regulation of the DNA damage response mediated by the heat shock response
| Project/Area Number |
22590264
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
ODA Tsukasa 群馬大学, 生体調節研究所, 助教 (10323643)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Takayuki 群馬大学, 生体調節研究所, 教授 (10166671)
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| Project Period (FY) |
2010 – 2012
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| Keywords | DNA 損傷 / 複製ストレス / HSP90 / 損傷乗越え DNA 合成 / 熱ショック応答 / HSF1 / 細胞老化 / p53 |
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| Research Abstract |
We found that the molecular chaperone HSP90 regulates the stability of REV1, a Y-family DNA polymerase, and accumulation of REV1 at DNA damage sites. 2) We showed that suppression of heat shock transcription factor (HSF1) induces cellular senescence mediated by activation of p53-p21 pathway.
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[Journal Article] Molecular Chaperone Hsp90 Regulates REV1-Mediated Mutagenesis2011
Author(s)
Mayca Pozo, F., Oda, T., Sekimoto, T., Murakumo, Y., Masutani, C., Hanaoka, F., Yamashita, T.
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Journal Title
Molecular and Cellular Biology
Volume: 16
Pages: 3396-3409
Peer Reviewed
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