2012 Fiscal Year Final Research Report
Role of SAP-1,a gastrointestinal-specific protein tyrosine phosphatase
| Project/Area Number |
22590265
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
MURATA Yoji 神戸大学, 医学研究科, 准教授 (60400735)
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| Project Period (FY) |
2010 – 2012
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| Keywords | チロシンホスファターゼ / 腸粘膜上皮細胞 / ケモカイン |
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| Research Abstract |
SAP-1 is a receptor-type tyrosine phosphatase that is specifically expressed at the microvillus of intestinal epithelial cells. In this study, the physiological and pathological roles of SAP-1 in the intestine were examined. I showed that the deficiency of Sap1 contributes to enhance colitis in IL-10 knockout mice, a mouse model for inflammatory bowel disease. I found that p100, a membrane protein, is a novel substrate for SAP-1 in the intestinal epithelial cells. Furthermore, I also found that SAP-1/p100 signal might be involved in the regulation of intestinal immunity through the production of chemokines by intestinal epithelial cells.
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[Journal Article] Dendritic cell-specific ablation of the protein tyrosine phosphatase shp1 promotes Th1 cell differentiation and induces autoimmunity.2012
Author(s)
Kaneko T., Saito Y., Kotani T., Okazawa H., Iwamura H., Sato-Hashimoto M., Kanazawa Y., Takahashi S., Hiromura K., Kusakari S.Kaneko Y., Murata Y., Ohnishi H., Nojima Y., Takagishi K., and Matozaki T.
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Journal Title
J. Immunol
Volume: 188
Pages: 5397-5407
DOI
Peer Reviewed
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[Journal Article] Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain2012
Author(s)
Maruyama T., Kusakari S., Sato-Hashimoto M., Hayashi Y., Kotani T., Murata Y., Okazawa H., Oldenborg P.-A., Kishi S., Matozaki T., and Ohnishi H.
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Journal Title
J. Neurochem
Volume: 121
Pages: 891-902
DOI
Peer Reviewed
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[Journal Article] Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.2011
Author(s)
Sato-Hashimoto M., Saito Y., Ohnishi H., Iwamura H., Kanazawa Y., Kusakari S., Kotani T., Mori M., Murata Y., Okazawa H., Ware CF., Olodenbrg PA., Nojima Y., and Matozaki T.
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Journal Title
J. Immunol
Volume: 187
Pages: 291-297
DOI
Peer Reviewed
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