Analysis of Mink1 in cell division

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590268
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Nagoya University
• Principal Investigator: ITO Satoko 名古屋大学, 医学系研究科, 助教 (30432256)
• Project Period (FY): 2010 – 2012
• Keywords: 細胞分裂 / Mink1 / セリンスレオニンキナーゼ

Research Abstract

To search for novel regulators of cytokinesis, we performed a screen using a library of siRNAs and found that Mammalian Misshapen-like kinase 1 (Mink1) was essential for cytokinesis. We found that Mink1 is required for the completion of abscission, the final stage of cytokinesis.

Research Products

• [Journal Article] The Aurora B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingression (2013)
  • Author(s): Asano E, Hasegawa H, Hyodo T, Ito S,Maeda M, Takahashi M, Hamaguchi M, Senga T
  • Journal Title: J Cell Sci Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] ALX1 Induces Snail Expression toPromote Epithelial-to-Mesenchymal Transition and Invasion of Ovarian Cancer Cells (2013)
  • Author(s): Yuan H, Kajiyama H, Ito S, Yoshikawa N, Hyodo T, Asano E, Hasegawa H, Maeda M, Shibata K, Hamaguchi M, Kikkawa F,Senga T
  • Journal Title: Cancer Res Volume: 73(5) Pages: 1581-90
  • Peer Reviewed
• [Journal Article] S100A10 is required for the organization of actin stress fibers and promotion of cell spreading (2013)
  • Author(s): Sayeed S, Asano E, Ito S, Ohno K,Hamaguchi M, Senga T
  • Journal Title: Mol Cell Biochem Volume: 374(1-2) Pages: 105-11
  • DOI: DOI:10.1007/s11010-012-1509-2
  • Peer Reviewed
• [Journal Article] Misshapen-likekinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for thecompletion of cytokinesis. (2012)
  • Author(s): Hyodo T, Ito S, Hasegawa H, Asano E,Hamaguchi M, Senga T
  • Journal Title: J Biol Chem Volume: 287(30) Pages: 25019-29
  • Peer Reviewed
• [Journal Article] Role of palladinphosphorylation by extracellular signal-regulatedkinase in cell migration (2011)
  • Author(s): Asano E, Maeda M, Hasegawa H, Ito S,Hyodo T, Yuan H, Takahashi M, Hamaguchi M, Senga T
  • Journal Title: PLoS One Volume: 6(12)
  • Peer Reviewed
• [Presentation] Mink1 is a novel somponent of STRIPAK and is required for the completion of cyotokinesis (2012)
  • Author(s): 兵頭寿典、伊藤聡子、長谷川仁紀、千賀威
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-11
• [Presentation] Mink1 is a novel somponent of STRIPAK and is required for the completion of cyotokinesis (2012)
  • Author(s): 兵頭寿典、伊藤聡子、千賀威
  • Organizer: 第6回ナノメディスン国際シンポジウム
  • Place of Presentation: 松江
  • Year and Date: 2012-11-30
• [Presentation] Mink1 is a novel somponent of STRIPAK and is required for the completion ofcyotokinesis (2012)
  • Author(s): 伊藤聡子、前田真男、浜口道成、千賀威
  • Organizer: 71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-26