2012 Fiscal Year Final Research Report
Roles of small GTPases and ROS in functions anddiseases of inner ear
| Project/Area Number |
22590271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
UEYAMA Takehiko 神戸大学, 自然科学系先端融合研究環バイオシグナル研究センター, 准教授 (80346254)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGUCHI Hirofumi 京都府立医科大学, 医学(系)研究科(研究院), 講師 (00515223)
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| Project Period (FY) |
2010 – 2012
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| Keywords | small GTPases / ROS / inner ear / hearing / balancing |
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| Research Abstract |
1. We engineered a genetically modified mice-line producing ROS, and found that the mice-line was vulnerable to noise exposure. The vulnerability to ROS was inhibited by the scavenger of ROS.
2. We engineered a knockout (KO) mice-line manifesting progressive hearing loss. Now we are extensively analyzing the molecular mechanism of deafness in the KO mice.
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