2012 Fiscal Year Final Research Report
Functional analysis of CIBZ, a methyl-CpG binding protein which is essential for the ES cell differentiation
| Project/Area Number |
22590272
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
MATSUDA Eishou 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (00335481)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ES 細胞 / 細胞増殖 / 細胞分化 / 細胞周期 / DNA メチル化 / 筋芽細胞分化 |
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| Research Abstract |
G1/S transition is important for embryonic stem cell (ESC) proliferation; however, the transcriptional factor that regulates this remains largely unknown. We present data showing that CIBZ, a transcription factor, regulates ESC proliferation and G1/S transition. Our results indicate that CIBZ-associated ESC proliferation and G1/S transition is dependent on Nanog expression.
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