2012 Fiscal Year Final Research Report
Elucidation of the mechanism underlying differentiation and function of Leydig cells through identification of enhanceosome.
| Project/Area Number |
22590273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
BABA Takashi 九州大学, 大学院・医学研究院, 助教 (40435524)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 核内受容体 / エネルギーホメオスタシス / レギュロン |
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| Research Abstract |
I investigated the mechanism of the transcriptional regulation of Ad4BP/SF-1 gene in Leydig cells. As a result, it was revealed that the expression of Ad4BP/SF-1 gene is regulated by Ad4BP/SF-1 itself. Further, I elucidated through a genome-wide analysis of target genes of Ad4BP/SF-1 that genes involved in the glycolytic pathway were targets of Ad4BP/SF-1.
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[Journal Article] Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes2013
Author(s)
Shima Y, Miyabayashi K, Haraguchi S, Arakawa T, Otake H, Baba T, Matsuzaki S, Shishido Y, Akiyama H, Tachibana T, Tsutsui K, Morohashi K
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Journal Title
Mol. Endocrinol
Volume: 27
Pages: 63-73
Peer Reviewed
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[Journal Article] Cbx2, a polycomb group gene, is required for Sry gene expression in mice2012
Author(s)
Katoh-Fukui Y, Miyabayashi K, Komatsu T, Owaki A, Baba T, Shima Y, Kidokoro T, Kanai Y, Schedl A, Wilhelm D, Koopman P, Okuno Y, Morohashi K
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Journal Title
Endocrinology
Volume: 153
Pages: 913-924
Peer Reviewed
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[Journal Article] Abnormal epithelial cell polarity and migration of Emx2 KO embryonic gonads induced by ectopic EGFRexpression2010
Author(s)
Masatomo Kusaka, Yuko Katoh-Fukui, Hidesato Ogawa, Kanako Miyabayashi, Takashi Baba,Yuichi Shima, Noriyuki Sugiyama, Yukihiko Sugimoto, Yasushi Okuno, Ryuji Kodama, Akiko Iizuka-Kogo, Takeo Senda, Toshikuni Sasaoka, Kunio Kitamura, Shinichi Aizawa, Ken-ic
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Journal Title
Endocrinology
Volume: 151
Pages: 5893-5904
Peer Reviewed
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