2012 Fiscal Year Final Research Report
Uncovering the molecular mechanism of c-Myc/Max transcriptional factor complex-mediated preservation of embryonic stem cell state
| Project/Area Number |
22590275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
OKUDA Akihiko 埼玉医科大学, 医学部, 教授 (60201993)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Hidemasa 埼玉医科大学, 医学部, 講師 (50292123)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 発生医学 |
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| Research Abstract |
Embryonic stem (ES) cells are defined by their two remarkable properties, i.e., pluripotent and indefinite self-renewal properties. Although some papers had suggested the involvement of Myc family proteins including c-Myc protein for sustaining these prominent properties which ES cells have, this issue has never been addressed from the gene targeting analyses. Therefore, we conducted homozygous knockout of Max gene encoding an indispensable partner protein for all three Myc proteins (c-Myc, N-Myc and L-Myc) to exert their transcriptional activities as well as oncogensis promoting activities.
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Research Products
(15 results)
