Role of coagulation factor XIII in invasion of macrophages

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590281
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Yamagata University
• Principal Investigator: SOURI Masayoshi 山形大学, 医学部, 准教授 (20292419)
• Project Period (FY): 2010 – 2012
• Keywords: XIII因子 / 架橋結合 / 炎症と血液凝固 / 単球 / マクロファージ

Research Abstract

A possible role of coagulation factor XIII (FXIII) in invasion of macrophages was examinedusing catalytic A subunit of FXIII (FXIII-A)-deficient mice. FXIII-A-deficient macrophagesshowed lower chemotactic ability than wildtype cells, although it was not stationerysignificant. In the heart tissue of lipopolysaccharide (LPS)-treated wildtype mice, type Icollagen transiently increased lesions where macrophages invaded. In contrast, depositionof type I collagen hardly increased in heart of FXIII-A-deficient mice treated with LPS.Thus, it was suggested that FXIII-A inside cells involved in chemotaxis of macrophages,and FXIII-A contributed to increase of type I collagen deposition in damaged tissues.

Research Products

• [Journal Article] Severe inhibitor-negative acquired factorXIII/13 deficiency with aggressivesubdural haemorrhage (2013)
  • Author(s): Kawano H, Yamamoto D, Uchihashi Y, Wakahashi K, Kawano Y, Sada A, Minagawa K, Katayama Y, Kohmura E,Souri M, Ichinose A.
  • Journal Title: Blood Coagul Fibrinolysis Volume: (印刷中)
  • DOI: doi:10.1097/MBC.0b013e32835facef
  • Peer Reviewed
• [Journal Article] Proteosomal degradation of naturallyrecurring R260C missense and exon-IVdeletion mutants of factor XIII A-subunit expressed in mammalian cells (2013)
  • Author(s): Zhang WG, Souri M, Ichinose A.
  • Journal Title: Haemophilia Volume: 19 Pages: 415-419
  • DOI: doi:10.1111/hae.12072.
  • Peer Reviewed
• [Journal Article] Alloantibodiesagainst the B subunit of plasma factor XIII developed in its congenital deficiency (2013)
  • Author(s): Wada H, Souri M, Matsumoto R, Sugihara T, Ichinose A.
  • Journal Title: Thromb Haemost Volume: 109 Pages: 661-668
  • URL: http://dx.doi.org/10.1160/TH12-12-0936
  • Peer Reviewed
• [Journal Article] Aggressive fatal case of autoimmunehemorrhaphilia resulting fromanti-Factor XIII antibodies (2013)
  • Author(s): Sugiyama H, Uesugi H, Suzuki S, Tanaka K, Souri M, Ichinose A.
  • Journal Title: Blood Coagul Fibrinolysis Volume: 24 Pages: 85-89
  • DOI: doi:10.1097/MBC.0b013e328358e8e7.
  • Peer Reviewed
• [Journal Article] Hemorrhagic-acquired factor XIIIdeficiency associated with tocilizumabfor treatment of rheumatoid arthritis (2012)
  • Author(s): Matsuoka M, Majima T, Onodera T, Ieko M, Souri M, Ichinose A, Kurita T, Kasahara Y, Inoue M, Takahashi D.
  • Journal Title: Int J Hematol Volume: 96 Pages: 781-785
  • DOI: doi:10.1007/s12185-012-1191-x.
  • Peer Reviewed
• [Journal Article] Impaired dimer assemblyand decreased stability of naturallyrecurring R260C mutant A subunit forcoagulation factor XIII (2012)
  • Author(s): Maeda S, Zhang WG, Souri M, Yee VC, Ichinose A.
  • Journal Title: J Biochem Volume: 152 Pages: 471-478
  • DOI: doi:10.1093/jb/mvs088.
  • Peer Reviewed
• [Journal Article] Molecular modeling predicts structuralchanges in the A subunit of factor XIIIcaused by two novel mutations identifiedin a neonate with severe congenital factor XIII deficiency (2012)
  • Author(s): Souri M, Yee VC, Fujii N, Ichinose A.
  • Journal Title: Thromb Res Volume: 130 Pages: 506-510
  • DOI: doi:10.1016/j.thromres.2012.05.003.
  • Peer Reviewed
• [Journal Article] A case of acquired FXIII deficiency with severebleeding symptoms (2012)
  • Author(s): Hayashi T, Kadohira Y, Morishita E, Asakura H, Souri M, Ichinose A.
  • Journal Title: Haemophilia Volume: 18 Pages: 618-620
  • DOI: doi:10.1111/j.1365-2516.2012.02763.x.
  • Peer Reviewed
• [Journal Article] A short half-life of the administered factor XIII (FXIII) concentrates after the firstreplacement therapy in a newborn withsevere congenital FXIII deficiency (2012)
  • Author(s): Fujii N, Souri M, Ichinose A.
  • Journal Title: Thromb Haemost Volume: 107 Pages: 592-4
  • URL: http://dx.doi.org/10.1160/TH11-09-0625
  • Peer Reviewed
• [Journal Article] Reduced difference of α-plasmin inhibitor levels between plasma and serum in patientswith severe factor XIII deficiency,including autoimmune hemorrhaphiliadue to anti-factor XIII antibodies (2012)
  • Author(s): Ichinose A, Souri M.
  • Journal Title: Int J Hematol Volume: 95 Pages: 47-50
  • DOI: doi:10.1007/s12185-011-0992-7
  • Peer Reviewed
• [Journal Article] Japanese collaborative research group on"Acquired haemorrha-philia due to factorXIII deficiency" (2011)
  • Author(s): Ichinose A, Souri M
  • Journal Title: As many as 12 caseswith haemorrhagic acquired factor XIIIdeficiency due to its inhibitors wererecently found in Japan. Thromb Haemost Volume: 105 Pages: 925-927
  • DOI: doi:10.1160/TH10-11-0724.
  • Peer Reviewed
• [Journal Article] Spontaneousregression of the inhibitor against thecoagulation factor XIII A subunit in acquired factor XIII deficiency (2010)
  • Author(s): Ishida F, Okubo K, Ito T, Okumura N, Souri M, Ichinose A.
  • Journal Title: ThrombHaemost Volume: 104 Pages: 1284-1285
  • DOI: doi:10.1160/TH10-06-0355.
  • Peer Reviewed
• [Presentation] 後天性血友病 XIII/13における抗 XIII因子自己抗体の阻害特性 (2012)
  • Author(s): 惣宇利正善,尾崎 司,一瀬白帝
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡)
  • Year and Date: 20121214-16
• [Presentation] 凝固 XIII因子 Aサブユニット欠損マウスにおける血球の分化について (2012)
  • Author(s): 惣宇利正善,一瀬白帝
  • Organizer: 第34回日本血栓止血学会学術集会
  • Place of Presentation: ハイアットリージェンシー東京(東京)
  • Year and Date: 20120607-09
• [Presentation] 生体内における細胞内凝固 XIII因子 Aサブユニットの新たな機能 (2011)
  • Author(s): 惣宇利正善,一瀬白帝
  • Organizer: 第84回日本生化学会大会シンポジウム[1S14pトランスグルタミナーゼ(タンパク質架橋化酵素)の進化と機能分化]
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 20110921-24
• [Presentation] Biochemical characterization of anti-factor XIII autoantibodies in patients with hemorrhagic acquiredfactor XIII deficiency (2011)
  • Author(s): Souri M, Iwata H, Zhang WG, Ichinose A
  • Organizer: XXIII Congress ofthe International Society on Thrombosisand Haemostasis (ISTH2011) and 57th Annual SSC Meeting
  • Place of Presentation: Kyoto International Conference Center(Kyoto, Japan)
  • Year and Date: 20110723-28
• [Presentation] 妊娠期の止血における凝固 XIII因子陽性細胞の存在意義 (2010)
  • Author(s): 惣宇利正善,張 偉光,岩田宏紀,一瀬白帝
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同年会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 20101207-10
• [Presentation] マクロファージのエンドトキシン誘導性組織内浸潤における XIII因子の関与 (2010)
  • Author(s): 惣宇利正善,張 偉光,岩田宏紀,一瀬白帝
  • Organizer: 第33回日本血栓止血学会学術集会
  • Place of Presentation: 城山観光ホテル(鹿児島)
  • Year and Date: 20100422-24
• [Book] 別冊日本臨床新領域別症候群シリーズ No.22血液症候群(第2版) II-その他の血液疾患を含めて- (2013)
  • Author(s): 惣宇利正善,一瀬白帝
  • Total Pages: 539-544
  • Publisher: 第XIII因子 Aおよび Bサブユニット欠損症
• [Remarks]
  • URL: http://www.id.yamagata-u.ac.jp/MolPathoBiochem/Bunbyo.html