2012 Fiscal Year Final Research Report
Influence on protein-tyrosine phosphorylation by hepatitis C virus in B cells
| Project/Area Number |
22590285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | University of Fukui |
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Principal Investigator |
SADA Kiyonao 福井大学, 医学部, 教授 (10273765)
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| Co-Investigator(Kenkyū-buntansha) |
CHIHARA Kazuyasu 福井大学, 医学部, 准教授 (00314948)
TAKEUCHI Kenji 福井大学, 医学部, 助教 (40236419)
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| Co-Investigator(Renkei-kenkyūsha) |
HOTTA Hak 神戸大学, 大学院・医学研究科, 教授 (40116249)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子病態学 |
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| Research Abstract |
We have focused on tyrosine phosphorylation of viral proteins as the pathogenesis of Hepatitis C virus (HCV) in B cells, and identified that HCV-NS5A protein associates with and activates protein-tyrosine kinase Fyn which regulates the tumor and immune signal transduction in B cells. This suggests that HCV infection may affect the dysfunction of B cells and immunological surveillance. In addition, we found the blood glucose concentration and AMP-activated protein kinase (AMPK) regulates HCV replication through the proteome analysis.
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[Journal Article] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells2012
Author(s)
Nakashima, K., Takeuchi, K., Chihara, K., Horiguchi, T., Sun, X., Deng, L., Shoji, I., Hotta, H., and Sada, K
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Journal Title
PLoS ONE
Volume: 7(10)
Pages: e46634
Peer Reviewed
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[Journal Article] Enhancement of B cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism2011
Author(s)
Ogi, K., Nakashima, K., Chihara, K., Takeuchi, K., Horiguchi, T., Fujieda, S., and Sada, K
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Journal Title
Genes Cells
Volume: 16(9)
Pages: 951-960
Peer Reviewed
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[Journal Article] Inhibitory effect of Acai (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation2011
Author(s)
Horiguchi, T., Ishiguro, N., Chihara, K., Ogi, K., Nakashima, K., Sada, K., and Hori-Tamura, N
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Journal Title
J. Agric. Food. Chem
Volume: 59(10)
Pages: 5595-5601
Peer Reviewed
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[Presentation] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells2012
Author(s)
Nakashima, K., Takeuchi, K., Chihara, K., Horiguchi, T., Sun, X., Deng, L., Shoji, I., Hotta, H., and Sada, K
Organizer
IUBMB&FEBS
Place of Presentation
Sevilla, Spain
Year and Date
2012-09-06
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[Presentation] Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and independent pathways2011
Author(s)
Nakashima, K., Takeuchi, K., Chihara, K., Hotta, H., and Sada, K
Organizer
IUMS 2011
Place of Presentation
Sapporo, Japan
Year and Date
2011-09-15
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