Analysis of new function of anti-inflammatory protein

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590288
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Suzuka University of Medical Science (2011-2012); Osaka City University (2010)
• Principal Investigator: SATO Eisuke 鈴鹿医療科学大学, 薬学部, 教授 (60211942)
• Project Period (FY): 2010 – 2012
• Keywords: アネキシン1 / 活性酸素 / アポトーシス / ネットーシス / 抗炎症タンパク質

Research Abstract

The anti-inflammatory protein annexin-1 is a potent mediator of inflammation resolution and a 37-kDa member of the annexin family of calcium and phospholipid-binding proteins, expressed constitutively in many cells, including neutrophil. The purpose of this study was to investigate the effect of annexin-1 protein as an endogenous regulator of anti-inflammatory effect and extracellular traps. Annexin1 directly bound to p65 of NF-kB. Annexin 1 also released to extracellular space with nuclear DNA during formation of extracellular traps.

Research Products

• [Journal Article] Ultraviolet B irradiation of the mouse eye induces pigmentation of the skin more strongly than does stress loading, by increasing the levels of prohormone convertase 2 and -melanocyte-stimulating hormone. (2013)
  • Author(s): Hiramoto K, Yamate Y, Kobayashi H, Ishii M, Sato EF, Inoue M
  • Journal Title: Clin Exp Dermatol. Volume: 38(1) Pages: 71-6
• [Journal Article] Ultraviolet B radiation to the eye induces pigmentation in the epidermis via the activation of the subunit gp91 phox of reduced nicotinamide adenine dinucleotide phosphate oxidase. (2012)
  • Author(s): Hiramoto K, Sato, EF
  • Journal Title: Clin Exp Dermatol Volume: 37(1) Pages: 65-67
• [Journal Article] Computational modeling of apoptotic signaling pathways induced by cisplatin. (2012)
  • Author(s): Hong JY, Kwon SS, Kim GH, Kim JW, Sato E, Cho KH, Shim EB.
  • Journal Title: BMC Systems Biology Volume: 6(1) Pages: 122
• [Journal Article] Effect of the smell of Seirogan, a wood creosote, on dermal and intestinal mucosal immunity and allergic inflammation. (2012)
  • Author(s): Hiramoto K, Yamate Y, Kobayashi H,Ishii M, Miura T, Sato EF, Inoue M.
  • Journal Title: J Clin Biochem Nutr. Volume: 51(2) Pages: 91-5
• [Journal Article] Intercellular pathway through hyaluronic acid in UVB-induced inflammation Experimental Dermatology (2012)
  • Author(s): Hiramoto, K; Kobayashi, H; Yamate,Y; Ishii, M; Sato, E
  • Volume: 21(12)
  • Pages: 911-4
• [Journal Article] A major protein of mycobacteria possesses ferritin (2011)
  • Author(s): M Takatsuka, M Osada-Oka, E Satoh, KKitadokoro, Y Nishiuchi , M Yoshimura , M Inoue , K Iwai , T Arakawa , Y Shimoji, H Ogura , K Kobayashi , A Rambukkana , S Matsumoto
  • Journal Title: superfamily protein-like activity and protects against DNA damage by Fenton reaction PLoS One Volume: 6(6) Pages: e20985
• [Journal Article] Ultraviolet-A irradiation to the eye modulates intestinal mucosal functions and properties of mast cells in the mouse (2011)
  • Author(s): Yamate, Y., Hiramoto, K., Sato, EF. Inoue, M.
  • Journal Title: Photochemistry and Photobiology Volume: 87(1) Pages: 191-198
• [Journal Article] Plasma cluster ions decrease the antigenicity of mite allergens and suppress atopic dermatitis in NC/Nga mice. (2011)
  • Author(s): Hiramoto K, Orita K, Yamate Y, Sato EF, Okano H, Nishikawa K, Inoue M.
  • Journal Title: Arch Dermatol Res Volume: 303(5) Pages: 367-70
• [Journal Article] Role of mitochondria in the maintenance of platelet function during in vitro storage. (2011)
  • Author(s): Hayashi T, Tanaka S, Hori Y, Hirayama F, Sato EF, Inoue M.
  • Journal Title: Transfus Med. Volume: 21(3) Pages: 166-74
• [Journal Article] Mitochondria determine the efficacy of anti-cancer agents that interact with DNA but not the cytoskeleton (2011)
  • Author(s): Hara, K., Kasahara, E., Takahashi,N., Konishi, M., Jikumaru, M., Inoue, J, Kubo, S., Okamura H., Sato, EF., Inoue, M.
  • Journal Title: Journal of Pharmacology and Experimental Therapeutics Volume: 337(3) Pages: 838-845
• [Journal Article] Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway. (2011)
  • Author(s): Kasahara E, Sekiyama A, Hori M, Hara K, Takahashi N, Konishi M, Sato EF, Matsumoto S, Okamura H, Inoue M.
  • Journal Title: FEBS Lett. Volume: 585(14) Pages: 2263-8
• [Journal Article] Increasedalpha-melanocyte-stimulating hormone(a-MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis (2010)
  • Author(s): Hiramoto K,Kobayashi, H., Sato EF, Inoue M.
  • Journal Title: Experimental Dermatology Volume: 19(2) Pages: 132-6
• [Journal Article] Role of Hypothalamo-Pituitary-Adrenal Axis in the Modulation of Pollinosis induced by Pollen Antigens. (2010)
  • Author(s): Hashimoto, M., Sato, EF., Hiramoto, K.,Kasahara, M. Inoue M
  • Journal Title: Allergology International Volume: 59 Pages: 201-206
• [Journal Article] Prevention of scattered light-induced asthenopia and fatigue by a polarized filter Photodermatology (2010)
  • Author(s): K Hiramoto, Y Yamate, K Orita, M Jikumaru, E Kasahara, EF. Sato, S Tamura & M Inoue
  • Journal Title: Photoimmunology and Photomedicine Volume: 26(2) Pages: 89-92
• [Journal Article] Strong exercise stress exacerbates dermatitis in atopic model mice (2010)
  • Author(s): K Orita, K Hiramoto, R Inoue, E F. Sato, Hi Kobayashi, M Ishii, M Inoue
  • Journal Title: NC/Nga mice, while proper exercise reduces it Experimental Dermatology Volume: 19(12) Pages: 1067-1072
• [Journal Article] Effect of oxidative stress during repeated ovulation on the structure and functions of the ovary (2010)
  • Author(s): K Miyamoto, EF. Sato*, H Tabata, M Katsuragi, K Hiramoto, E Kasahara, and M Inoue1
  • Journal Title: oocytes and their mitochondria Free Radical Biology and Medicine Volume: 49 Pages: 674-681
• [Journal Article] Role of hydrogen generation by Klebsiella pneumoniae in the oral cavity of human subjects (2010)
  • Author(s): T Kanazuru, EF. Sato, K Nagata, H Matsui, K Watanabe, E Kasahara, M Jikumaru, J Inoue and M Inoue
  • Journal Title: The Journal of Microbiology Volume: 48(6) Pages: 778-783
• [Journal Article] Alpha-melanocyte-stimulating hormone plays an important role in the onset of pollinosis in a pollen allergy mouse model. (2010)
  • Author(s): Hiramoto K, Hashimoto M, Orita K, Jikumaru M, Sato EF, Inoue M.
  • Journal Title: Int Arch Allergy Immunol. Volume: 153(1) Pages: 13-8
• [Presentation] 排卵におけるミトコンドリアと活性酸素代謝 (2012)
  • Author(s): 佐藤英介
  • Organizer: 第30回日本受精着床学会
  • Year and Date: 20120000
• [Presentation] 生殖現象における活性酸素代謝とミトコンドリアの役割 (2011)
  • Author(s): 佐藤英介
  • Organizer: 第32回日本炎症・再生学会
  • Year and Date: 20110000
• [Presentation] Characterization of extracellular traps of oral neutrophils.
  • Author(s): EF Sato, et al.
  • Organizer: 16th SFRRI meeting in London.
• [Presentation] Effect of lipid peroxidation in rat liver mitochondria and its regulation.
  • Author(s): Imada I, EF Sato et al.
  • Organizer: 16th SFRRI meeting in London
• [Book] Analysis of Immunological reactions to Nanoscale Foods: Possible occurrence of Allergic reaction to nanoscale Food Particles.A Revolution in Food,Biomedical and Health Sciences (2012)
  • Author(s): EF Sato, M Hashimoto, M Inoue
  • Total Pages: 305-309
  • Publisher: Eds D Bagchi, M Bagchi, H Moriyama, F Shahidi.