2012 Fiscal Year Final Research Report
Pathophysiological analysis of acute muscle atrophy by failure of cysteine biosynthesis and development of its control strategy
| Project/Area Number |
22590292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Keio University |
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Principal Investigator |
ISHII Isao 慶應義塾大学, 薬学部, 准教授 (90292953)
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| Project Period (FY) |
2010 – 2012
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| Keywords | システイン / 筋萎縮症 / ホモシステイン / アミノ酸代謝 / 硫化水素 / オートファジー / ミオパシー / イメージング |
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| Research Abstract |
We have developed mice lacking cystathionine gamma-lyase (CTH), the final step enzyme for cysteine biosynthesis, and observed acute muscle atrophy when f ed a cyst(e)ine-deficient diet. Our pathological, immunohistochemical, and biochemical analyses revea
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Research Products
(23 results)
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[Journal Article] Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria.2012
Author(s)
Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I
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Journal Title
Free Radic Biol Med
Volume: 52
Pages: 1716-1726
DOI
Peer Reviewed
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[Journal Article] Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.2012
Author(s)
Morikawa T, Kajimura M, Nakamura T, Hishiki T, Nakanishi T, Yukutake Y, Nagahata Y, Ishikawa M, Hattori K, Takenouchi T, Takahashi T, Ishii I, Matsubara K, Kabe Y, Uchiyama S, Nagata E, Gadalla MM, Snyder SH, Suematsu M
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Journal Title
Proc Natl Acad Sci USA
Volume: 109
Pages: 1293-1298
DOI
Peer Reviewed
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[Journal Article] Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria.2011
Author(s)
Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I
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Journal Title
Anal Bioanal Chem
Volume: 400
Pages: 1853-1863
DOI
Peer Reviewed
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