2012 Fiscal Year Final Research Report
Regulation of inflammation and metabolism by vitamin Dreceptor in hepatic immune cells
| Project/Area Number |
22590294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Kenichi 日本大学, 医学部, 講師 (20366602)
UMEDA Kaori (遠藤 香織) 日本大学, 医学部, 助手 (10445744)
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| Research Collaborator |
SEKI Shuji 防衛医科大学校, 医学教育部医学科専門課, 教授 (80531392)
ISHIZAWA Michiyasu 日本大学, 医学部, 助手 (30646542)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ビタミンD受容体 / 胆汁鬱滞 / 炎症 / インターロイキン6 / マクロファージ / NKT細胞 / NK細胞 / ノックアウトマウス |
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| Research Abstract |
Vitamin D receptor (VDR) responds to the active form of vitamin D3 and the bile acid lithocholic acid. We investigated the role of VDR in hepatic immune cells. VDR played a limited role in regulation of hepatic genes involved in metabolism and immunity in mice with cholestasis. Inflammatory responses were suppressed in the intestine of VDR-null mice. Increased NK cells and iNKT cells were observed in mononuclear cells from the liver of VDR-null mice. The results show a role of VDR in the intestine-liver pathway.
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