2012 Fiscal Year Final Research Report
Molecular mechanism of regulation of expression and identificati on of novel target gene of vitamin D in the pancreas
| Project/Area Number |
22590295
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
CHOI Mihwa 日本大学, 医学部, 助教 (30571012)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Hisamitsu 日本大学, 医学部, 教授 (60361086)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKISHIMA Makoto 日本大学, 医学部, 教授 (70346146)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子病態学 / 膵臓学 / ビタミンD / 標的遺伝子 |
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| Research Abstract |
We found that Pyy is a VDR target gene in the mouse pancreas. VDR activation increased mRNA and protein expression of PYY in the pancreatic islets of mice and pancreatic endocrine cell lines, but did not change intestinal PYY expression.
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