2012 Fiscal Year Final Research Report
Methods of genome-wide gene-gene interaction analysis
| Project/Area Number |
22590300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Yamagata University |
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Principal Investigator |
TAMIYA Gen 山形大学, 医学部, 教授 (10317745)
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| Co-Investigator(Kenkyū-buntansha) |
UEKI Masao 山形大学, 医学部, 助教 (10515860)
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| Project Period (FY) |
2010 – 2012
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| Keywords | SNP-GWAS / SNPs / ゲノムワイド関連解析 / モデル選択 / 変数選択 / 遺伝子×遺伝子相互作用 / 高次元変数選択 |
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| Research Abstract |
We propose utilizing a model selection strategy for an exhaustive interaction analysis in whole GWA data. Our new software, EPISIS, implements the ‘sure independence screening', which has two major parts, screening and variable selection;EPISIS can complete an exhaustive search for all possible SNP by SNP interactions innon-filtered GWA data within several days under common computing environments. Ourfast program is applied to find novel genetic components in GWA data from WTCCC (Wellcome Trust Case-Control Consortium).
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[Journal Article] Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes2012
Author(s)
Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S.
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Journal Title
J Allergy Clin Immunol
Volume: 129(5)
Pages: 1413-1416
DOI
Peer Reviewed
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[Journal Article] Polymorphism of proinflammatory cytokine genes and albuminuria in the Japanese general population: the Takahata study2011
Author(s)
Mashima Y, Konta T, Kudo K, Suzuki K, Ikeda A, Ichikawa K, Shibata Y, Watanabe T, Tamiya G, Kato T, Kawata S, Kubota I.
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Journal Title
Nephrol Dial Transplant
Volume: 26(12)
Pages: 3902-3907
DOI
Peer Reviewed
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