2012 Fiscal Year Final Research Report
Neural differentiation dysfunction in cells with autosomal imbalance
Project/Area Number |
22590301
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human genetics
|
Research Institution | Tottori University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Keywords | ゲノム医科学 |
Research Abstract |
Although particular chromosomal syndromes are phenotypically and clinically distinct, the majority of individuals with autosomal imbalance, such as Down syndrome, manifest mental retardation. To study the developmental stages of complex neuronal diseases, several independent disomic and trisomic human ES (T21-hES) and iPS (DS-iPS) cell lines were generated and subsequently differentiated into neuronal progenitor cells. Whereas T21-ES and DS-iPS cells generated neurons similarly to disomic control cells, expression pattern of neural differentiation markers in these cells was different from that of controls.
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Research Products
(5 results)
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[Journal Article] Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study2012
Author(s)
Imaoka N, Hiratsuka M, Osaki M, Kamitani H, Kambe A, Fukuoka J, Kurimoto M, Nagai S, Okada F, Watanabe T, Ohama E, Kato S, Oshimura M
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Journal Title
Oncol. Rep
Volume: 28
Pages: 923-930
DOI
Peer Reviewed
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[Journal Article] Integration-free iPS cells engineered using human artificial chromosome vectors2011
Author(s)
Hiratsuka MD S-i PS 6 -1 2ectoderm mesoderm endodermD S-i PS 8 -3図3 ダウン iPS 細胞の in vivo 3 胚葉分化, Uno N, Ueda K, Kurosaki H, Imaoka N, Kazuki K, Ueno E, Akakura Y, Katoh M, Osaki M, Kazuki Y, Nakagawa M, Yamanaka S, Oshimura M.
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Journal Title
PLoS One
Volume: 6
Pages: e25961
DOI
Peer Reviewed
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[Journal Article] Refined human artificial chromosome vectors for gene therapy and animal transgenesis2011
Author(s)
Kazuki K, Hoshiya H, Takiguchi M, Abe S, Iida Y, Osaki M, Katoh M, HiratsukaM, Shirayoshi Y, Hiramatsu K, Ueno E, Kajitani N, Yoshino T, Kazuki K, Ishihara C, Takehara S, Tsuji S, Ejima F, Toyoda A, Sakaki Y, Larionov V, Kouprina N, Oshimura M
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Journal Title
Gene The
Volume: 18
Pages: 384-93
DOI
Peer Reviewed
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