2012 Fiscal Year Final Research Report
Study on histopathological biomarker in cervical lesions based on HPV subtypes and integration status of HPV within host genome
| Project/Area Number |
22590306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Gunma University |
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Principal Investigator |
SANO Takaaki 群馬大学, 大学院・医学系研究科, 准教授 (90292581)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Tomomi 群馬大学, 医学部保健学科, 助教 (00312893)
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| Project Period (FY) |
2010 – 2012
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| Keywords | HPV / p16 蛋白 / L1 蛋白 / 免疫染色 / 子宮頸癌 / 異形成 / 腺癌 |
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| Research Abstract |
Human papillomavirus (HPV) L1 capsid protein (L1) is associated with the productive phase of HPV infection. We examined the relationship between L1 and p16 expression in cervical intraepithelial neoplasia. A study compared the usefulness of self-collected (SC)materials for cervical cytology and HPV genotyping. These results suggest that a combination of Pap and HPV tests on SC material may provide a diagnostic strategy with high sensitivity and specificity. A study evaluated the usefulness of p16/Ki-67 as a new biomarker in the diagnosis of cervical lesions. The p16/Ki-67 double immunostaining in cytology sample is useful as a surrogate marker of high-grade lesions.
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