2012 Fiscal Year Final Research Report

Alteration of apical-basal polarity regulating proteins Par/Lgl/Scrib in lung adenocarcinomas and its relationship with invasion and metastasis

Research Project

Project/Area Number	22590309
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Human pathology
Research Institution	Tokyo Medical and Dental University
Principal Investigator	AKASHI Takumi 東京医科歯科大学, 医学部附属病院, 准教授 (60242202)
Co-Investigator(Kenkyū-buntansha)	FUJIWARA Naoyuki 東京医科歯科大学, 医学部附属病院, 助教 (80451912)
Project Period (FY)	2010 – 2012
Keywords	肺癌 / 極性 / 浸潤突起
Research Abstract	Epithelial cells have an apical surface facing a lumen and a basal surface facing extracellular matrix. Abnormality of apical-basal polarity in neoplastic change was examined in the aspect of localization of invadopodia proteins in lung adenocarcinomas. Actinin-1 and cortactin showed matrix-contact-side localization in adenocarcinoma cells, but rarely in normal bronchiolar epithelial cells, alveolar cells, or precursor neoplastic lesions. Matrix-contact-side localization of invadopodia-related proteins could be histological markers indicative for invasion, metastasis, and poor prognosis. Rho guanine exchange factor/Ect2, one of Par6-binding proteins, was a possible regulator of polarity abnormality in lung adenocarcinomas.