Fundamental research on target therapies for hormone-resistant prostate cancer

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590320
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nihon University (2011-2012); Tokai University (2010)
• Principal Investigator: TANG Xiaoyan 日本大学, 医学部, 助教 (20326036)
• Co-Investigator(Renkei-kenkyūsha): MASUDA Shinobu 日本大学, 医学部, 教授 (20276794) ; TAKEKOSHI Susumu 東海大学, 医学部・病態病理学, 准教授 (70216878) ; OSAMURA Yoshiyuki 国際医療福祉大学, 病理学, 教授 (10100992) ; MIYAGI Youhei 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター臨床研究所分子病態学部 (00254194)
• Project Period (FY): 2010 – 2012
• Keywords: 前立腺癌 / ホルモン治療 / ソマトスタチン

Research Abstract

Somatostatins are a family of cyclopeptides that act as inhibitors of various secretory processes and cell proliferation, by binding to somatostatin receptors on target cells. Somatostatin peptide agonists were introduced into clinical practice for the treatment of hormone-secreting pituitary adenomas and gastroenteropancreatic (GEP) tumours. In this study, we revealed that somatostatin receptor mRNA expression of prostate cancer cell lines can be up-regulated by DNA methylation inhibitor (5'-aza, decitabine) and histone deacetylase inhibitor (TSA), especially when we incubated those prostate cancer cells in an androgen - free medium (charcoal filtrated serum) . The results suggest that somatostatin peptide agonists may be a new treatment for hormone-resistant prostate cancer patients.

Research Products

• [Journal Article] Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer viaPin1-proteomicanalysis. (2012)
  • Author(s): Endoh K, Nishi M, Ishiguro H, Uemura H, Miyagi Y, Aoki I, Hirano H, Kubota Y, Ryo A.
  • Journal Title: Prostate Volume: 72(6) Pages: 626-37
  • Peer Reviewed
• [Journal Article] Overview of the prostate cancer pathology. (2011)
  • Author(s): Miyagi Y, Harada M.
  • Journal Title: NihonRinsho 69 Suppl Volume: 5 Pages: 25-30
  • Peer Reviewed
• [Journal Article] Somatostatin analogue inhibits the mobility of prostate carcinoma cells: A new therapeutic method for advanced prostate carcinoma. (2010)
  • Author(s): Tang XY, Takekoshi S, Itoh J, Umemura S, Shoji S, Terachi T, Osamura RY
  • Journal Title: International Journal of Oncology Volume: 37 Pages: 1077-1083
  • Peer Reviewed
• [Journal Article] Metastin has Potential as a Suitable Biomarker and Novel Effective Therapy for Cancer Metastasis. (2010)
  • Author(s): Shoji S, Tang XY, Sato H, Usui Y, Uchida T, Terachi T
  • Journal Title: OncologyLetters Volume: 1 Pages: 783-788
  • Peer Reviewed
• [Journal Article] Overexpression of fatty acid binding protein-7 correlates with basal-like subtype cancer. (2010)
  • Author(s): Tang XY, Umemura S, Tsukamoto H, Kumaki N, Tokuda Y, Osamura RY
  • Journal Title: Pathology-research andpractice Volume: 206 Pages: 98-101
  • Peer Reviewed
• [Journal Article] ETS family-associated gene fusions in Japanese prostate cancer: analysis of 194 radical prostatectomy samples. (2010)
  • Author(s): Miyagi Y, Sasaki T, Fujinami K, Sano J, Senga Y, Miura T, Kameda Y, Sakuma Y, Nakamura Y, Harada M, Tsuchiya E.
  • Journal Title: ModPathol Volume: 23(11) Pages: 1492-8
  • Peer Reviewed
• [Presentation] メチル化阻害・抑制剤およびソマトスタチンアナログ製剤によるホルモン不応性前立腺癌細胞に於けるSSTR1-5の発現誘導. (2012)
  • Author(s): 唐小燕、中村圭靖、宮城洋平、増田しのぶ.
  • Organizer: 101回病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] 血漿遊離アミノ酸プロファイルに基づく新規マーカー,アミノインデックスによる前立腺がんのスクリーニング. (2010)
  • Author(s): 三浦猛,森山正敏,池田伊知郎,猿木信裕,山本浩史,今泉明,光島徹,山門實,宮城洋平.
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪.
  • Year and Date: 2010-09-24
• [Presentation] SSTR2aをターゲットとする前立腺癌の分子標的治療に関する基礎的研究 (2010)
  • Author(s): 唐小燕,梅村しのぶ.竹腰進
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-27