2012 Fiscal Year Final Research Report
Molecular pathological analysis of hepatocyte nuclear factor 4α
| Project/Area Number |
22590331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Niigata University |
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Principal Investigator |
UMEZU Hajim 新潟大学, 医歯学総合病院, 准教授 (50251799)
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Makoto 新潟大学, 医歯学系, 教授 (30045786)
HASEGAWA Go 新潟大学, 医歯学系, 准教授 (90251800)
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| Project Period (FY) |
2010 – 2012
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| Keywords | HNF-4α (hepatocyte nuclear factor-4α) / アイソフォーム / 免疫組織学 / 肺腺癌 / 肝細胞癌 |
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| Research Abstract |
Hepatocyte nuclear factor-4α (HNF4α) is a member of the nuclear receptor superfamily involved in endodermal development and hepatocyte differentiation. The expression of HNF4α isoforms is specific to the cell type in normal tissues. Using antibodies recognizing P1- and P2-isoforms, we investigate pulmonary adenocarcinoma and hepatocellular carcinoma. Thyroid transcription factor-1 (TTF-1) is highly expressed in a large proportion of pulmonary adenocarcinoma; however, most TTF-1-negative pulmonary adenocarcinomas were mucinous lesions with the predominant expressions of HNF4α. The higher expression of P2-isoform was observed in low histological grading of hepatocelluar carcinomas and was regarded as an index to predict poor prognosis of the patients.
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[Journal Article] The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma2011
Author(s)
Kunii R, Jiang S, Hasegawa G, Yamamoto T, Umezu H, Watanabe T, Tsuchida M, Hahimoto T, Hamakubo T, Kodama T, Sasai K, Naito M
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Journal Title
Histopathology
Volume: 58(3)
Pages: 467-476
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