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2012 Fiscal Year Final Research Report

High-throughput tumor-related gene expression analysis in various cell lines.

Research Project

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Project/Area Number 22590334
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionYamaguchi University

Principal Investigator

KONDO Tomoko  山口大学, 大学院・医学系研究科, 助教 (30379979)

Project Period (FY) 2010 – 2012
Keywordsイメージサイトメトリー / 腫瘍マーカー / セルアレイ / 網羅的解析
Research Abstract

We analyzed expression level of tumor makers in many cell lines by ‘cell array system’ which we developed for high content analysis. The expression level of 24 kinds of intracellular molecules was measured in various cell lines by Laser scanning cytometer (LSC). We tried novel classification of tumors based on the data we obtained, but we did not succeed.

  • Research Products

    (12 results)

All 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (3 results)

  • [Journal Article] DNA copy number aberrations associated with lymphovascular invasion in upper urinary tract urothelial carcinoma2012

    • Author(s)
      Misumi T, Yamamoto Y, Miyachika Y, Eguchi S, Chochi Y, Nakao M, Nagao K, Hara T, Sakano S, Furuya T, Oga A, Kawauchi S, Sasaki K, Matsuyama H
    • Journal Title

      Cancer Genet

      Volume: 205 Pages: 313-318

    • DOI

      DOI:10.1016/j.cancergen.2012.04.008

    • Peer Reviewed
  • [Journal Article] subtypes of breast cancer consist of a mixture of tumors with different genotype2012

    • Author(s)
      Yanagawa M, Ikemot K, Kawauchi S, Furuya T, Yamamoto S, Oka M, Oga A, Nagashima Y, Sasaki K. Luminal A and luminal B
    • Journal Title

      BMC Res Notes

      Volume: 25 Pages: 376

    • DOI

      DOI:10.1186/1756-0500-5-376

    • Peer Reviewed
  • [Journal Article] BCL2L10 protein regulates apoptosis/proliferation through differential pathways in gastric cancer cells2011

    • Author(s)
      Xu JD, Cao XX, Long ZW, Liu XP, Furuya T, Xu JW, Liu XL, De Xu Z, Sasaki K, Li
    • Journal Title

      J Pathol.

      Volume: 223 Pages: 400-409

    • DOI

      DOI:10.3892/or.2011.1246

    • Peer Reviewed
  • [Journal Article] A simple method for enhancing hybridization efficiency in chromosome and array comparative genomic hybridization2011

    • Author(s)
      Kawauchi S, Furuya T, Nakao M, Ikemoto K, Oga A, Sasaki K
    • Journal Title

      Biotech Histochem

      Volume: 86 Pages: 192-198

    • DOI

      DOI:10.3109/10520291003666781

    • Peer Reviewed
  • [Journal Article] DNA copy number aberrations associated with the clinicopathological features of colorectal cancers: Identification of genomic biomarkers by array-based comparative genomic hybridization2011

    • Author(s)
      Nakao M, Kawauchi S, Uchiyama T, Acachi J, Ito H, Chochi Y, Furuya T, Oga A, Sasaki K
    • Journal Title

      Oncology report

      Volume: 25 Pages: 1603-1611

    • DOI

      DOI:10.3892 /or.2011.1246

    • Peer Reviewed
  • [Journal Article] Centrosome amplification as a putative prognostic biomarker for the classification of urothelial carcinomas2011

    • Author(s)
      Yamamoto Y, Misumi T, Eguchi S, Chochi Y, Kitahara S, Nakao M, Nagao K, Hara T, Sakano S, Furuya T, Oga A, Kawauchi S, Sasaki K, Matsuyama H
    • Journal Title

      Hum Pahol

      Volume: 42 Pages: 1923-1930

    • DOI

      DOI:10.1016/j.humpath.2011.02.013

    • Peer Reviewed
  • [Journal Article] Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma2011

    • Author(s)
      Oga A, Uchida K, Nakao M, Kawauchi S, Furuya T, Chochi Y, Ikemoto K, Okada T, Ueyama Y, Sasaki K, Yousefpour F
    • Journal Title

      Oncol Rep

      Volume: 23 Pages: 1393-1398

    • DOI

      DOI:10.3892/or.2011.1446

    • Peer Reviewed
  • [Journal Article] DNA copy number aberrations associated with aneuploidy and chromosomal instability in breast cancers2010

    • Author(s)
      Kawauchi S, Furuya T, Ikemoto K, Nakao M, Yamamoto S, Oka M, Sasaki K
    • Journal Title

      Oncol Rep

      Volume: 24 Pages: 875-883

    • Peer Reviewed
  • [Journal Article] Loss of BCL2L10 protein expression as prognostic predictor for poor clinical outcome in gastric carcinoma2010

    • Author(s)
      Xu JD, Furuya T, Cao XX, Liu XL, Li QQ, Wang WJ, Xu ZD, Sasaki K, Liu XP
    • Journal Title

      Histopathology

      Volume: 57 Pages: 814-824

    • Peer Reviewed
  • [Presentation] 各種乳癌培養細胞に対する 12q15 領域にコードされる遺伝子産物の影響2012

    • Author(s)
      古屋智子、伊藤秀明、帖地康世、小賀厚徳、河内茂人、佐々木功典
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2012-04-27
  • [Presentation] 乳癌におけるDNAコピー数異常領域に存在する遺伝子産物の乳癌培養細胞に対する影響についての検討2011

    • Author(s)
      古屋智子、河内茂人、帖地康世、伊藤秀明、小賀厚徳、佐々木功典
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2011-04-29
  • [Presentation] 乳癌におけるDNAコピー数異常と各種マーカーの発現との関連について2010

    • Author(s)
      古屋智子、河内茂人、帖地康世、小賀厚徳、佐々木功典
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2010-04-29

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Published: 2014-08-29  

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