2013 Fiscal Year Final Research Report
Analyses of influence by Warburg Effect small molecular Metbolites via Cancer-Stroma interactions
| Project/Area Number |
22590342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
FUJII GEN 独立行政法人国立がん研究センター, 研究所, 主任研究員 (90321877)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | がん間質相互作用 / ワールブルグ効果 |
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| Research Abstract |
Local fluctuations of small molecular metabolic products concentration, like lactate or pyruvate produced with Warburg effect, were frequently seen in and around cancer tissue. In this research plan, we investigate molecular influences and mechanism of unique expression due to these metabolites concentration changes, via cancer - stroma interaction, for organization, maintenance, and exacerbation of cancer.
Using co-cultured cell model system composed with cancer cell and stroma cell, we successfully perused semi-independent expression profiles of each cell group from integrated DNA chip expression data with novel bio-informatics techniques. Several gene products were extracted, and certified as these expressions were specifically responded to those metabolite concentration changes. Molecular signal transduction pathways were presumed by experiments using reagents showing resembled molecular - structure with small molecular metabolites, inhibitors, and activators for Warburg effect.
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Ulcer Res
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Author(s)
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Ulcer Res
Volume: 39
Pages: 201-206
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