2012 Fiscal Year Final Research Report
The relationship among the genotypes of ALDH, telomere length, and chromosomal instability in the esophageal epithelium.
| Project/Area Number |
22590343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
IZUMIYAMA Naotaka 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 助手 (10158751)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kenichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60159069)
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| Co-Investigator(Renkei-kenkyūsha) |
AIDA Junko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (80425678)
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| Project Period (FY) |
2010 – 2012
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| Keywords | テロメア / ALDH / Q-FISH / 食道 |
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| Research Abstract |
The investigation of the telomere lengths in the esophageal epithelium revealed that there is no difference among the ALDH genotype in telomere lengths, but the epithelium has short telomeres in the large iodine-unstained lesions with multiplicity. Telomere shortening may not generate cancer directly, but may create conditions under which SCC can develop more easily, depending on subsequent exposure to carcinogens.
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Research Products
(15 results)
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[Journal Article] Accelerated in vivo epidermal telomere loss in Werner syndrome2011
Author(s)
Ishikawa N, Nakamura K, Izumiyama-Shimomura N, Aida J, Ishii A, Goto M, Ishikawa Y, Asaka R, Matsuura M, Hatamochi A, Kuroiwa M, Takubo K.
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Journal Title
Aging
Volume: 3
Pages: 417-429
Peer Reviewed
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