2012 Fiscal Year Final Research Report
Elucidation of physiological significance of Txnip suppression and Redox regulation under innate immune response.
| Project/Area Number |
22590345
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
KANARI Yasuyoshi 東北大学, 大学院・生命科学研究科, 助教 (60351590)
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| Co-Investigator(Renkei-kenkyūsha) |
MUTA Tatsushi 東北大学, 大学院・生命科学研究科, 教授 (60222337)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 炎症 / 代謝 / Toll様受容体 / 解糖系 |
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| Research Abstract |
Whereas a number of inflammatory genes are induced by activation of nuclear factor-κB and other transcription factors, Txnip are dramatically suppressed by almost proinflammatory stimuli in many types of cells. Suppression of Txnip by LPS is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei and dissociation of the MondoA:Mlx complex that bound to the carbohydrate-response elements in the Txnip promoter in unstimulated cells. This observation links between inflammatory responses and metabolic regulation.
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[Journal Article] An evolutionary analysis of RAC2 identifies haplotypes associated with human autoimmune diseases2011
Author(s)
Sironi M, Guerini FR, Agliardi C, Biasin M, Cagliani R, Fumagalli M, Caputo D, Cassinotti A, Ardizzone S, Zanzottera M, Bolognesi E, Riva S, Kanari Y, Miyazawa M, Clerici M
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Journal Title
Mol Biol Evol
Volume: 28(12)
Pages: 3319-29
DOI
Peer Reviewed
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