2012 Fiscal Year Final Research Report
Significance of triglyceride metabolism in human vascular smooth muscle cell phenotype
| Project/Area Number |
22590349
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | University of the Ryukyus |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KATO Seiya 琉球大学, 大学院・医学研究科, 教授 (60268844)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 血管平滑筋細胞 / トリグリセリド / 脂質代謝 / ATGL |
|---|
| Research Abstract |
VSMC could use TG mediated ATGL as an cellular energy. TG load in VSMC provided TG accumulation and enhanced TG metabolism and associated with inflammatory phenotype. In addition, coordination of ATGL expression level and beta-oxidation level was probably responsible for inflammatory phenotype. We believe that this culture model is useful in resolution of inflammatory mechanism in neointima and relationship between TG metabolism and atherosclerosis.
|
