2012 Fiscal Year Final Research Report
Cancer stem-like cells with the characteristics of mesenchymal cells and the vascular niche
| Project/Area Number |
22590357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 幹細胞 / 間葉系 / ニッチ |
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| Research Abstract |
We found that the nestin-negative glioma cells were grown around the nestin-positive glioma cells growing in perivascular in the subcutaneous tumors grown as xenografts in nude mice. By using FACS, these two populations were successfully harvested. Global gene expression profiles demonstrated that some mesenchymal markers were up-regulated in the nestin-positive glioma cells. In the prescence of TGF-beta, nestin-positive glioma cells differentiated into myofibroblasts and osetoblasts. We also found that nestin-positive glioma cells were more resistant to anti-cancer reagents compared with nestine-negative glioma cells. Taken together, nestin-positive glioma cells were considered to be more undifferentiated than nestin-negative glioma cells.
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[Journal Article] Effects of intrapulmonary viral tropism and cytokine expression on the histological patterns of cytomegalovirus pneumonia2012
Author(s)
Arai Y, Tsuchida T, Kosugi I, Kawasaki H, Meguro S, Kinoshita M, Baba S, Maeda M, Shinmura Y, Tsutsui Y, Iwashita T
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Journal Title
Pathol Int
Volume: 62(9)
Pages: 628-39
DOI
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