Possible mechanisms of galectin-9-induced immunoregulatory macrophages

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590360
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kagawa University
• Principal Investigator: HIRASHIMA Mitsuomi 香川大学, 医学部, 客員研究員 (70109700)
• Co-Investigator(Kenkyū-buntansha): OOMIZU Souichi 香川大学, 医学部, 助教 (00444729) ; NIKI Toshiro 香川大学, 医学部, 助教 (40558508)
• Project Period (FY): 2010 – 2012
• Keywords: ガレクチン 9 / 免疫学 / 癌 / 炎症 / マクロファージ

Research Abstract

We described that galectin-9 regulates functions of not only immunocompetent cells but also various cells by collaboration with world-wide investigators. From our works, it is suggested that galectins including galectin-9 play a role as an important factor to overcome stress, because galectins are conserved longtime from fungi and sea sponge to human.

Research Products

• [Journal Article] HCV-infected hepatocytes drive CD4+ CD25+ Foxp3+ regulatory T-cell development through the Tim-3/Gal-9 pathway. (2013)
  • Author(s): Ji XJ, Ma CJ, Wang JM, Wu XY, Niki T,Hirashima M, Moorman JP, Yao ZQ
  • Journal Title: Eur J Immunol. Volume: 43 Pages: 458-67
• [Journal Article] A possible role of galectin-9 in the pulmonary fibrosis of patients with interstitial pneumonia (2013)
  • Author(s): Matsumoto N, Katoh S, Yanagi S, Arimura Y, Tokojima M, Ueno M, Hirashima M, Nakazato M.
  • Journal Title: Lung Volume: 191 Pages: 191-8
• [Journal Article] Self-association of the galectin-9 C-terminal domain via the opposite surface of the sugar-binding site (2013)
  • Author(s): Nonaka Y, Ogawa T, Oomizu S, Nakakita SI, Nishi N, Kamitori S,Hirashima M, Nakamura T.
  • Journal Title: J Biochem. Volume: 153 Pages: 463-71
• [Journal Article] Galectin-9 functionally impairs natural killer cells in humans and mice. (2013)
  • Author(s): Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR.
  • Journal Title: J Virol Volume: 87 Pages: 4838-45
• [Journal Article] Galectin-9 in cancer therapy (2013)
  • Author(s): Fujihara S, Mori H, Kobara H, Rafiq K, Niki T, Hirashima M, Masaki T.
  • Journal Title: Recent Pat Endocr Metab Immune Drug Discov Volume: 7 Pages: 130-7
• [Journal Article] Galectin-9 Ameliorates Clinical Severity of MRL/lpr Lupus-Prone Mice by Inducing Plasma Cell Apoptosis Independently of Tim-3. (2013)
  • Author(s): Moritoki M, Kadowaki T, Niki T, Nakano D, Soma G, Mori H, Kobara H, Masaki T, Kohno M, Hirashima M.
  • Journal Title: PLoS One Volume: 8 Pages: e60807
• [Journal Article] The increase of plasma galectin-9 in a patient with insulin allergy: a case report. (2012)
  • Author(s): H. Chagan-Yasutan, B. Shiratori, UR. Siddiqi, H. Saitoh, Y. Ashino, T.Arikawa, M. Hirashima, T. Hattori.
  • Journal Title: Clin Mol Allergy Volume: 8 Pages: 12(1-4)
• [Journal Article] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages. (2012)
  • Author(s): Kadowaki T, Arikawa T, Shinonaga R, Oomizu S, Inagawa H, Soma G, Niki T, Hirashima M
  • Journal Title: Clin Immunol Volume: 142 Pages: 296-307
• [Journal Article] Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner (2012)
  • Author(s): Oomizu S, Arikawa, T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hirashima M
  • Journal Title: Clin Immunol Volume: 143 Pages: 51-58
• [Journal Article] Galectin-9 ameliorates herpes simplex-induced inflammation through apoptosis (2012)
  • Author(s): Shim JA, Park S, Lee ES, Niki T, Hirashima M, Sohn S
  • Journal Title: Immunobiology Volume: 217 Pages: 657-66
• [Journal Article] Tim-3 is an inducible human NK cell receptor that enhances interferon gamma production in response to galectin-9 (2012)
  • Author(s): MK. Gleason, TR. Lenvik, V. McCullar, M.Felices, MS. O'Brien, SA. Cooley, MR. Verneris, F. Cichocki, CJ. Holman, A.Panoskaltsis-Mortari, T. Niki, M.Hirashima, B.R. Blazar, JS. Miller
  • Journal Title: Blood Volume: 119 Pages: 3064-72
• [Journal Article] IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma (2012)
  • Author(s): ZZ. Yang, DM. Grote, SC. Ziesmer, T. Niki, M. Hirashima, AJ. Novak, TE. Wizig, SM. Ansell.
  • Journal Title: J. Clin Invest Volume: 122 Pages: 1271-82
• [Journal Article] Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection (2012)
  • Author(s): S. Elahi, T. Niki, M. Hirashima, H. Horton.
  • Journal Title: Blood Volume: 120 Pages: 682-90
• [Journal Article] The glycan-binding protein Galectin-9 has direct apoptotic activity towards melanoma cells (2012)
  • Author(s): Wiersma VR, de Bruyn M, van Ginkel RJ, Sigar E, HirashimaM, Niki T, Nishi N, Samplonius DF, Helfrich W, Bremer E.
  • Journal Title: J Invest Dermatol Volume: 132 Pages: 2302-5
• [Journal Article] Contrasting acute graft-versus-host disease effects ofTim-3/galectin-9 pathway blockade dependent upon the presence ofdonor regulatory T cells. (2012)
  • Author(s): Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VKK, Blazar BR.
  • Journal Title: Blood Volume: 120 Pages: 682-90
• [Journal Article] A novel monoclonal antibody fordetection ofgalectin-9 intissue sections: application tohuman tissues infected byoncogenic viruses. (2012)
  • Author(s): Barjon C, Niki T, Verillaud B, Opolon P, Bedossa P,Hirashima M, Blanchin S, Wassef M, Rosen HR, Jimenez AS, Wei M, Busson P
  • Journal Title: Infect Agent Cancer Volume: 7 Pages: 16
• [Journal Article] TNFRSF25 Agonistic Antibody andGalectin-9 Combination Therapy Controls Herpes Simplex Virus-Induced Immunoinflammatory Lesions. (2012)
  • Author(s): J Reddy PB, Schreiber TH, Rajasagi NK, Suryawanshi A, Mulik S, Veiga-Parga T, Niki T, Hirashima M, Podack ER, Rouse BT
  • Journal Title: J Virol Volume: 86 Pages: 10606-20
• [Journal Article] Tumor-infiltrating DCssuppress nucleic acid-mediated innate immune responses through interactions between thereceptor TIM-3 and thealarmin HMGB1. (2012)
  • Author(s): Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M.
  • Journal Title: Nat Immunol Volume: 13 Pages: 832-42
• [Journal Article] Rapid Decrease ofPlasma Galectin-9 Levels inPatients with Acute HIVInfection after Therapy (2012)
  • Author(s): Saitoh H, Ashino Y, Chagan-Yasutan H, Niki T, Hirashima M, Hattori T.
  • Journal Title: Tohoku J Exp Med Volume: 228 Pages: 157-61
• [Journal Article] Cell surface galectin-9 expressing th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion (2012)
  • Author(s): Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hattori T, Masaki T, Hirashima M.
  • Journal Title: PLoS One Volume: 7 Pages: e48574
• [Journal Article] Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis (2011)
  • Author(s): Sakai K., Kawata E., Ashihara E., Nakagawa Y., Yamauchi A., Yao H., Nagao R., Tanaka R., Yokota A., Takeuchi M., Hirai H., Kimura S., Hirashima M., Yoshimura N., Maekawa T.
  • Journal Title: Eur J Immunol Volume: 41 Pages: 67-75
• [Journal Article] Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. (2011)
  • Author(s): Vega-Carrascal I, Reeves EP, Niki T, Arikawa T, McNally P, O'Neill SJ, Hirashima M, McElvaney NG.
  • Journal Title: J. Immunol. Volume: 186 Pages: 2897-909
• [Journal Article] Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect. (2011)
  • Author(s): Iqbal AJ, Sampaio AL, Maione F, Greco KV, Niki T, Hirashima M, Perretti M, Cooper D.
  • Journal Title: Am. J. Pathol. Volume: 178 Pages: 1201-09
• [Journal Article] Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells. (2011)
  • Author(s): Lv K, Xu W, Wang C, Niki T, Hirashima M, Xiong S.
  • Journal Title: Clin Immunol Volume: 140 Pages: 92-101
• [Journal Article] Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. (2011)
  • Author(s): Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR.
  • Journal Title: Blood Volume: 117 Pages: 4501-10
• [Journal Article] Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages. (2011)
  • Author(s): Kojima K, Arikawa T, Saita N, Goto E, Tsumura S, Tanaka R, Masunaga A, Niki T, Oomizu S, Hirashima M, Kohrogi H.
  • Journal Title: Am J Respir Crit Care Med Volume: 184 Pages: 328-39
• [Journal Article] Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency. (2011)
  • Author(s): Reddy PB, Sehrawat S, Suryawanshi A, Rajasagi NK, Mulik S, Hirashima M, Rouse BT
  • Journal Title: J Immunol Volume: 187 Pages: 5748-55
• [Journal Article] Galectin-9 expands immunosuppressive macrophages to ameliorate T cell-mediated lung inflammation. (2010)
  • Author(s): Arikawa T, Saita N, Oomizu S, Ueno M, Matsukawa A, Katoh S, Kojima K, Nagahara K, Miyake M, Yamauchi A, Kohrogi H, and Hirashima M.
  • Journal Title: Eur J Immunol Volume: 40 Pages: 548-58
• [Journal Article] Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways (2010)
  • Author(s): T. Kobayashi, J. Kuroda, E.Ashihara, S. Oomizu, Y. Terui, A. Taniyama, S. Adachi, T. Takagi, M. Yamamoto, N Sasaki, S Horiike, K. Hatake, A. Yamauchi, M.Hirashima, M. Taniwaki.
  • Journal Title: Leukemia Volume: 24 Pages: 843-50
• [Journal Article] Galectin-9 induces osteoblast differentiaion through the CD44/Smad signaling pathway. (2010)
  • Author(s): R. Tanikawa, T.Tanikawa, M. Hirashima, A. Yamauchi, Y.Tanaka.
  • Journal Title: BBRC Volume: 394 Pages: 317-22
• [Journal Article] Targeting activating transcription factor 3 by galectin-9 induces apoptosis and overcomes various types of treatment resistance in chronic myelogenous leukemia. (2010)
  • Author(s): J. Kuroda, M.Yamamoto, H. Nagoshi, T. Kobayashi, N. Sasaki, Y Shimura, S Horiike, S. Kimura, A. Yamauchi, M. Hirashima, M.Taniwaki.
  • Journal Title: Molecular Cancer Research Volume: 8 Pages: 994-1001
• [Journal Article] Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells., Valerie Dardalhon, AC. Anderson (2010)
  • Author(s): J.Karman, L. Apetoh, R. Chandwaskar, DH. Lee, M.Cornejo, N. Nishi, A. Yamauchi, FJ. Quintana, RA. Sobel, M. Hirashima, VK. Kuchroo.
  • Journal Title: J. Immunol. Volume: 185 Pages: 1383-92
• [Journal Article] Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells. (2010)
  • Author(s): Rashmi Mishra, Michal Grzybek, Toshiro Niki, Mitsuomi Hirashima, Kai Simons.
  • Journal Title: PNAS Volume: 107 (41) Pages: 17633-38
• [Journal Article] A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in chronic hepatitis C infection. (2010)
  • Author(s): John A. Mengshol, Lucy Golden-Mason, Tomohiro Arikawa, Maxwell Smith, Toshiro Niki, Ryan McWilliams, Jessica Randall, Rachel McMahan, Manu Rangachari, Evgenia Dobrinskikh, Pierre Busson, Stephen J. Polyak, Mitsuomi Hirashima, Hugo R. Rosen.
  • Journal Title: Plos One Volume: 5(3) Pages: e9504
• [Journal Article] Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8+ T cell response (2010)
  • Author(s): Sharvan Sehrawat, Pradeep B J Reddy, Naveen Rajasagi, Amol Suryawanshi, Mitsuomi Hirashima, Barry T Rouse.
  • Journal Title: PLOS Pathogens Volume: 6 (5) Pages: e1000882
• [Journal Article] Determination of carbohydratebinding preferences of human galectins with carbohydrate microarrays. (2010)
  • Author(s): T.Horlacher, M A. Oberli, DB. Werz, LH. Krock, S. Bufali, B. Stocker, R. Mishra, J. Sobek, K. Simons, M. Hirashima, T. Niki, PH. Seeberger.
  • Journal Title: ChemBioChem Volume: 11 Pages: 1563-73
• [Journal Article] X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose (2010)
  • Author(s): H. Yoshida, M. Teraoka, N. Nishi, S. Nakakita, T. Nakamura, M.Hirashima. S. Kamitori.
  • Journal Title: J Biol Chem Volume: 285 Pages: 36969-76