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2012 Fiscal Year Final Research Report

Fundamental study of patholofgival role of CCL8 in GVHD

Research Project

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Project/Area Number 22590365
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionSapporo Medical University

Principal Investigator

KOKAI Yasuo  札幌医科大学, 医学部, 教授 (20178239)

Project Period (FY) 2010 – 2012
Keywords再生医学 / 造血幹細胞移植 / 移植片対宿主病 / GVHD / バイオマーカー / 客観診断 / 治療効果判定 / 予後予測
Research Abstract

The early and preclinical expression of CCL8 in plasma predicts overall survival of GVHD in vivo. Together with an involvement of allorecognition in CCL8 expression, it suggests that CCL8 plays an important role in GVHD pathology.

  • Research Products

    (5 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Remarks (1 results)

  • [Journal Article] Evaluation of annexin A5 as a biomarker for Alzheimer's disease and Dementia with Lewy bodies2013

    • Author(s)
      Sohma H, Imai S, Takei N, Honda H, Matsumoto K, Utsumi K, Matsuki K, Hashimoto E, Saito T, Kokai Y
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 5 Pages: 15-23

    • Peer Reviewed
  • [Journal Article] Metalothionein deficiency in the injured peripheral nerves of complex regional pain syndrome as revealed by proteomics2012

    • Author(s)
      Oki G, Wada T, Iba K, Aiki H, Sasaki K, Imai S, Sohm H, Matsumoto K, Yamaguchi M, Fujimiya M, Yamashita T, Kokai Y
    • Journal Title

      Pain

      Volume: 153 Pages: 532-9

    • Peer Reviewed
  • [Journal Article] Early expression of plasma CCL8 closely correlates with survival rate of acute graft-versus-host disease in mice2011

    • Author(s)
      Yamamoto M, Ota A, Hori T, Imai S, Sohma H, Suzuki N, Hatakeyama N, Inazawab N, Ito M-Y, Kimura H, Tsutsumi H, Kokai Y
    • Journal Title

      Exp Hematol

      Volume: 39(11) Pages: 1101-11112

    • Peer Reviewed
  • [Journal Article] Apolipoprotein E4 freauencies in Japanese population with Alzheimer's disease and dementia with Lewy bodies2011

    • Author(s)
      Kobayashi S, Tateno M, Woo T, Utsumi K, Sohma H, Ito Y-M, Kokai Y, Saito T
    • Journal Title

      PLos ONE

      Volume: 6(4) Pages: 1-5

    • Peer Reviewed
  • [Remarks]

    • URL

      http://web.sapmed.ac.jp/bme/

URL: 

Published: 2014-08-29  

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