2012 Fiscal Year Final Research Report
Therapeutic approach to lung cancer and malignant mesothelioma by inhibition of VEGR-VEGFR pathway
| Project/Area Number |
22590366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kyorin University (2011-2012)
Yokohama City University (2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAZAWA Takuya 杏林大学, 医学部, 准教授 (50251054)
OKUDELA Koji 横浜市立大学, 医学部, 助教
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血管内皮増殖因子 / Egr-1 / 肺癌 |
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| Research Abstract |
In summary, we have demonstrated that Early Growth Response Protein (Egr)-1 up-regulates the expression of VEGF-A in lung cancer cells by binding at specific sites in the VEGF-A promoter and that NAB2, a Egr-1 corepressor, probably form a negative feedback system for the Egr-1-VEGF-A expression. Egr-1 and NAB-2 may be useful as novel pharmaceutical targets in lung cancers.
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[Journal Article]2013
Author(s)
Sakata R, Shimoyamada H, Yanagisawa M, Murakami T, Makiyama K, Nakaigawa N, Inayama Y, Ohashi K, Nagashima Y, Yao M, Kubota Y
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Journal Title
Nonfunctioning juxtaglomerular cell tumor.
Pages: 973865
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[Journal Article] POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer2013
Author(s)
Ishii J, Sato H, Sakaeda M, Shishido-Hara Y, Hiramatsu C, Kamma H, Shimoyamada H, Fujiwara M, Endo T, Aoki I, Yazawa T.
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Journal Title
Pathol Int.
Volume: 63(3)
Pages: 158-68
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[Journal Article] Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer2013
Author(s)
Sakaeda M, Sato H, Ishii J, Miyata C, Kamma H, Shishido-Hara Y, Shimoyamada H, Fujiwara M, Endo T, Tanaka R, Kondo H, Goya T, Aoki I, Yazawa T.
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Journal Title
Lab Invest
Volume: 93(4)
Pages: 408-21
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[Journal Article] Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells2012
Author(s)
Kashiwagi K, Ishii J, Sakaeda M, Arimasu Y, Shimoyamada H, Sato H, Miyata C, Kamma H, Aoki I, Yazawa T.
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Journal Title
Pathol Int.
Volume: 62(4)
Pages: 232-45
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[Journal Article] Insulin-like growth factor binding protein-4 gene silencing in lung adenocarcinomas.2011
Author(s)
Sato H, Sakaeda M, Ishii J, Kashiwagi K, Shimoyamada H, Okudela K, Tajiri M, Ohmori T, Ogura T, Woo T, Masuda M, Hirata K, Kitamura H, Yazawa T.
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Journal Title
Pathol Int.
Volume: 61(1)
Pages: 19-27
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[Journal Article] Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells.2010
Author(s)
Shimoyamada H, Yazawa T, Sato H, Okudela K, Ishii J, Sakaeda M, Kashiwagi K, Suzuki T, Mitsui H, Woo T, Tajiri M, Ohmori T, Ogura T, Masuda M, Oshiro H, Kitamura H
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Journal Title
Am J Pathol
Volume: 177(1)
Pages: 70-83
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[Journal Article] Morphometric profiling of lung cancers-its association with clinicopathologic, biologic, and molecular genetic features2010
Author(s)
Okudela K, Woo T, Mitsui H, Yazawa T, Shimoyamada H, Tajiri M, Ogawa N, Masuda M, Kitamura H.
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Journal Title
Am J Surg Pathol
Volume: 34(2)
Pages: 243-55
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