2012 Fiscal Year Final Research Report
Functional analyses of sporozoite rhoptry proteins in Plasmodium
| Project/Area Number |
22590379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Ehime University |
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Principal Investigator |
ISHINO Tomoko 愛媛大学, 大学院・医学系研究科, 准教授 (40402680)
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| Co-Investigator(Renkei-kenkyūsha) |
TOKUNAGA Naohito 愛媛大学, 総合科学研究支援センター, 技術員 (30596151)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 寄生虫学 / スポロゾイト / オルガネラ / ロプトリー / 唾液腺 |
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| Research Abstract |
To elucidate the molecular mechanisms of sporozoites invasion, we focused on RON2, the secretory proteins localized to rhoptries. First, we developed the sporozoite-stage specific gene silencing system by promoterswapping. Using ron2 silencing transgenic sporozoites, it is revealed that RON2 has important roles both in salivary glands and liver invasion. Furthermore, we have identified 6 other sporozoite rhoptry proteins.
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