2012 Fiscal Year Final Research Report
IgE-mediated host defense mechanism during Strongyloides venezuelensisinfection
| Project/Area Number |
22590384
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Kenji 兵庫医科大学, 医学部, 教授 (60172350)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 免疫 / 抗体 / 蠕虫 |
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| Research Abstract |
Activation-induced cytidine deaminase-deficient (AID-/-) mice, lacking the ability to switch IgM to other isotypes, required much longer period to expel S.venezuelensis than wild-type (WT) mice. Adoptive transfers of immune sera from S. venezuelensis-infected mice restored AID-/- mice to promptly expelled S.venezuelensis. Immune serum-derived IgG and IgE induced worm expulsion via Fc γ receptor III (FcγRIII) and Fc ε receptor I (FcεRI), respectively. IgG and IgE played redundant roles but acted in concert to promote S.venezuelensis expulsion. My findings also suggest that mast cells are cellular targets of IgG and IgE.
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