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2012 Fiscal Year Final Research Report

Function and biosynthetic machinary of complex N-glycans expressing in Trypanosoma brucei

Research Project

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Project/Area Number 22590385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionMatsuyama University

Principal Investigator

NAKANISHI Masayuki  松山大学, 薬学部, 准教授 (00281048)

Project Period (FY) 2010 – 2012
Keywordsアフリカ睡眠病 / 糖転移酵素
Research Abstract

Trypanosoma brucei, a causative agent of African sleeping sickness, expresses complex type N-linked glycans which are supposed to have critical roles for its growth. We established thee strains of gene knock-out mutants and identified two genes that were involved in the synthesis of complex type N-linked glycans. Analysis of the strains showed the terminal structures of the glycans were not critical for the normal growth of the parasite.

  • Research Products

    (5 results)

All 2012 2011 2010

All Presentation (5 results)

  • [Presentation] β3糖転移酵素ファミリーに属するアフリカトリパノソーマ原虫酵素の機能解析2012

    • Author(s)
      中西雅之,白石喬寛,野元裕
    • Organizer
      第10回分子寄生虫・マラリアフォーラム
    • Place of Presentation
      群馬
    • Year and Date
      2012-10-13
  • [Presentation] アフリカトリパノソーマ原虫においてN-結合型複合糖鎖の合成に関与する糖転移酵素2011

    • Author(s)
      中西雅之,野元裕
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
  • [Presentation] Deletion of a putative glycosyltransferase gene from chromosome 8 in Trypanosoma brucei reduces the size of N-glycans2011

    • Author(s)
      Masayuki Nakanishi, Hiroshi Nomoto
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-09
  • [Presentation] Deletion of a glycosyltransferase gene, TbGT8, in Trypanosoma brucei affects the size of a 57 kDa protein in the mammalian stage2010

    • Author(s)
      中西雅之,井上 弥希,好井啓輔,野元裕
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
  • [Presentation] Disruption and characterisation of glycosyltransferases encoded by genes on chromosome 8 of Trypanosoma brucei2010

    • Author(s)
      Masayuki Nakanishi, Hiroaki Arioka, Miki Inoue, Hiroshi Nomoto
    • Organizer
      The XIIth International Congress of Parasitology 2010
    • Place of Presentation
      オーストラリア
    • Year and Date
      2010-08-18

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Published: 2014-08-29  

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