Study on schistosome's suppressive mechanisms against Th17-type inflammation

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590386
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: OSADA Yoshio 産業医科大学, 医学部, 准教授 (80282515)
• Co-Investigator(Kenkyū-buntansha): KURODA Etsushi 大阪大学, 免疫学フロンティア研究センター, 准教授 (10299604)
• Co-Investigator(Renkei-kenkyūsha): NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
• Project Period (FY): 2010 – 2012
• Keywords: 免疫修飾 / 感染症 / 炎症 / 寄生虫 / 自己免疫疾患 / 糖尿病 / サイトカイン

Research Abstract

We examined suppressive effects of Sohistosozzia mansoni infection on treptozotocin (STZ)-induced type l diabetes and spontaneous arthritis in IL-1 receptor antagonist-deficient mice. Schistosome infection significantly supPressed hyperglycemia induced by STZ. In the infected mice, pancreatic lymph node expressions of ・-cell toxic mediators were down-regulated in the infected mice. Th2 cytokines were dispensable for this anti-diabetic effect. Schistosome infection also suppressed hind paw edema in the spontaneous arthritis.

Research Products

• [Journal Article] Origin of a novel protein-coding gene family with similar signal sequence in Schistosoma japonicum (2012)
  • Author(s): Mbanefo EC, Chuanxin Y, Kikuchi M, Shuaibu MN, Boamah D, Kirinoki M, Hayashi N, Chigusa Y, Osada Y, Hamano S, Hirayanla K
  • Journal Title: BMC Genomics Volume: 13(260)
  • DOI: DOI:10.1186/1471-2164-13-260.
  • Peer Reviewed
• [Journal Article] 日本住血吸虫と神経系 (2012)
  • Author(s): 金澤保 長田良雄
  • Journal Title: 神経内科 Volume: 77(3) Pages: 267-273
• [Journal Article] Cerebral schistosomiasis due to Schistosoma haematobium confirmed by PCR analysis of brain specimen (2011)
  • Author(s): Imai K, Koibuchi T, Kumagai T, Maeda T, Osada Y, Ohta N, Koga M, Nakamura H, Miura T, Iwamoto A, Fujii T
  • Journal Title: J Clin Microbiol Volume: 49(10) Pages: 3703-3706
  • DOI: DOI:10.1128/JCM.01073-11.
  • Peer Reviewed
• [Journal Article] Schistosome: its benefit and harm in patients suffering from concomitant diseases (2011)
  • Author(s): Osada Y, Kanazawa T
  • Journal Title: J Biomed Biotechnol Volume: 2011(264173)
  • DOI: DOI:10.1155/2011/264173.
  • Peer Reviewed
• [Journal Article] 寄生虫とアレルギーの親密な関係 (2010)
  • Author(s): 長田良雄
  • Journal Title: Medical Practice Volume: 27(9) Pages: 1541-1542
• [Presentation] STZ投与マウス膵臓の炎症メディエーター発現に対する寄生蠕虫の効果 (2012)
  • Author(s): 長田良雄、山田壮亮、金澤保
  • Organizer: 第65回日本寄生虫学会南日本支部大会・第62回日本衛生動物学会南日本支部大会合同大会
  • Place of Presentation: 長崎
  • Year and Date: 20121110-11
• [Presentation] Helminths reduce severity of experimental type l diabetes in mice via STAT6- and IL-10- independent mechanisms. Forum Cheju 15 (2012)
  • Author(s): Osada Y, Yamada Y, Kanazawa T
  • Organizer: The 15th Japan-Korea Parasitologists' Seminar. Current Trends in Parasitology Research in Japan and Korea
  • Place of Presentation: 宮崎
  • Year and Date: 20120523-25
• [Presentation] マンソン住血吸虫が実験的1型糖尿病マウス膵臓の遺伝子発現に及ぼす効果 (2012)
  • Author(s): 長田良雄、藤山智宏、山田壮亮、金澤保
  • Organizer: 第82回日本寄生虫学会大会
  • Place of Presentation: 東京
  • Year and Date: 20120329-31
• [Presentation] 寄生蠕虫の抗糖尿病効果に関与する因子の解析 (2012)
  • Author(s): 長田良雄、山田壮亮、金澤保
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 西宮
  • Year and Date: 20120323-24
• [Presentation] Heligmosomoides polygyrus 感染はマウスのストレプトゾトシン誘発糖尿病を抑制する (2011)
  • Author(s): 長田良雄、山田壮亮、山岸靖宣、金澤保
  • Organizer: 第80回日本寄生虫学会大会
  • Place of Presentation: 東京
  • Year and Date: 20110717-18
• [Presentation] 腸管寄生虫感染はマウスのストレプトゾトシン誘発糖尿病を抑制する (2011)
  • Author(s): 長田良雄、山田壮亮、金澤保
  • Organizer: 第32回日本炎症・再生医学会
  • Place of Presentation: 京都
  • Year and Date: 20110602-03
• [Presentation] コラーゲン関節炎に対する蠕虫感染の影響-Heligmosomoides polygurysの場合- (2010)
  • Author(s): 長田良雄、黒田悦史、金澤保
  • Organizer: 第63回日本寄生虫学会南日本支部大会・第60回日本衛生動物学会南日本支部大会・合同大会
  • Place of Presentation: 鹿児島
  • Year and Date: 20101106-07
• [Presentation] Experimental Sehis tosoma mansoni infection suppresses autoimmune arthritis in mice (2010)
  • Author(s): Osada Y
  • Organizer: EPS Global-Shanghai 1st International Biomedicine Forum
  • Place of Presentation: 中国/上海
  • Year and Date: 20100910-11
• [Presentation] Sohistosoma mansoni has anti-arthritic effects accompanied with IL-17' s down-modulation dependent on viable eggs (2010)
  • Author(s): Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T
  • Organizer: XIIth International Congress of Parasitology
  • Place of Presentation: オーストラリア/メルボルン
  • Year and Date: 20100815-20
• [Presentation] 住血吸虫によるThサイトカイン修飾に関与する因子の解析 (2010)
  • Author(s): 長田良雄、金澤保
  • Organizer: 第79回日本寄生虫学会大会
  • Place of Presentation: 旭川
  • Year and Date: 20100520-21
• [Presentation] 住血吸虫による関節炎抑制には、炎症性サイトカインの産生抑制が伴う (2010)
  • Author(s): 長田良雄、清水少一、熊谷貴、山田壮亮、金澤保
  • Organizer: 第75回日本インターフェロン・サイトカイン学会
  • Place of Presentation: 北九州
  • Year and Date: 2010-06-25
• [Book] Parasitic Helminths as Potential Therapeutic Agents against Autoimmune Disorders In: Autoimmune Disorders-Current Concepts and Advances from Bedside to Mechanistic Insights (2011)
  • Author(s): Osada Y
  • Total Pages: 591-614 (Chapter 29)
  • Publisher: InTech
  • URL: DOI:10.5772/21640
• [Remarks] Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T. Schistosoma mansoni has anti-arthritic effects accompanied with IL-17' s down-modulation depent on viable eggs. Proceedings of XIIth International Congress of Parasitology. 113-116,2010. (国際学会会議録)