2012 Fiscal Year Final Research Report
Amelioration of murine listeriosis in the absence of NK cells and NKT cells and the analysis of the influence of double-stranded RNA on anti-bacterial resistance
| Project/Area Number |
22590388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Gunma University |
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Principal Investigator |
EMOTO Yoshiko 群馬大学, 大学院・保健学研究科, 研究員 (30542344)
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| Co-Investigator(Kenkyū-buntansha) |
EMOTO Masashi 群馬大学, 大学院・保健学研究科, 教授 (70232981)
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| Project Period (FY) |
2010 – 2012
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| Keywords | リステリア / 細胞内寄生細菌 / NK 細胞 / 二本鎖 RNA / PolyI:C |
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| Research Abstract |
NK1.1^+ cells have been considered to play a protective role in various bacterial infections by secreting IFN-・upon infection. Yet, we have obtained the first evidence that NK cells play a detrimental role in protection against intracellular bacteria, Listeria monocytogenes. In contrast, we also found that anti-listerial resistance was markedly enhanced by PolyI:C and that NK cells participate in this mechanism. Thus, because our findings clearly demonstrated the new role of NK cells in intracellular bacterial infection, we consider it likely that our study contributes to the development not only of bacteriology, but also of immunology.
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