2012 Fiscal Year Final Research Report
Study of mechanisms of repression of immune response at early stage of EHEC/EPEC infection
| Project/Area Number |
22590389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka University |
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Principal Investigator |
TOBE Toru 大阪大学, 大学院・医学系研究科, 教授 (70207596)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 病原性 |
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| Research Abstract |
By encountering pathogens hostcells induce inflammatory responses and activate immune responseto prevent infection of pathogens. Enterohaemorrhagic or enteropathogenic Escherichia coli (EHEC or EPEC) have ability to reduce these immune response at early stage of infection, and this ability could be important for successful infection.In this study, we identified several virulence factors involving suppression of inflammatory response and regulation of apoptosis in epithelial and immune cells.
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Research Products
(6 results)
