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2012 Fiscal Year Final Research Report

Analysis of new NLRP3 activation passway by Vibrio cholerae

Research Project

  • PDF
Project/Area Number 22590396
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionUniversity of the Ryukyus

Principal Investigator

NAKASONE Noboru  琉球大学, 大学院・医学研究科, 助教 (80175497)

Co-Investigator(Renkei-kenkyūsha) SUZUKI Toshihiko  琉球大学, 大学院・医学研究科, 教授 (10292848)
Project Period (FY) 2010 – 2012
Keywords感染免疫 / 炎症反応
Research Abstract

The purpose of this study is to isolate a MyD88/Trif independent NLRP3 activator from Vibrio cholerae O1 and clarified the signaling passway . We usedseveral factors of V.cholerae for the purpose, and we found that the hemolysin (HlyA) is most possible factor in V. cholerae. We also found that other bacterial hemolysins did not show same phenomenon. However, we could not obtain the certificate evidences.

  • Research Products

    (6 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Vibrio parahaemolyticus effector proteins suppress inflammasome activation by interfering with host autophagy signaling2013

    • Author(s)
      Higa N, Toma C, Koizumi Y, Nakasone N, Nohara T, Masumoto J, Kodama T, Iida T, Suzuki T
    • Journal Title

      PLOS Pathogen

      Volume: 9 Pages: e1003142

    • Peer Reviewed
  • [Journal Article] Inflammasome activation via intracellular NLRs triggered by bacterial infection2012

    • Author(s)
      Koizumi Y, Toma C, Higa N, Nohara T,Nakasone N, Suzuki T
    • Journal Title

      Cell Microbiol

      Volume: 14 Pages: 149-154

    • Peer Reviewed
  • [Journal Article] Detergents enhance EspB secretion from Escherichia coli strains harboring the locus for the enterocyte effacement (LEE) gene2011

    • Author(s)
      Nakasone N, Toma C, Higa N, Koizumi Y, Ogura Y and Suzuki T
    • Journal Title

      Microbiol Lett

      Volume: 315 Pages: 109-114

    • Peer Reviewed
  • [Presentation] The plant extracts which inhibit typeIII secretion in enteropathogenic and enterohaemorrhagic Escherichia coli2013

    • Author(s)
      Nakasone N. Higa N, Nohara,Takaesu G, Nohara T, Toma C, Suzuki T
    • Organizer
      第86回細菌学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2013-03-18
  • [Presentation] Analysis of the virulence factors involved in Leptospira interrogans-macrophage interactions2013

    • Author(s)
      Toma C, Higa N, Nakasone N, Nohara T,Koizumi N, Suzuki T
    • Organizer
      86回細菌学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2013-03-18
  • [Remarks]

    • URL

      http://w3.u-ryukyu.ac.jp/bacteriology/

URL: 

Published: 2014-08-29  

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