2012 Fiscal Year Final Research Report
The clarification of mechanisms for cytotoxic effect of Legionella hyper-toxic mutants which are intracellular growth-deficient (Toxh mutants) on host cells.
| Project/Area Number |
22590398
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of Shizuoka |
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Principal Investigator |
MIYAKE Masaki 静岡県立大学, 薬学部, 講師 (00295560)
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| Project Period (FY) |
2010 – 2012
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| Keywords | Legionella pneumophila / 宿主細胞内増殖 / 強細胞毒性 / アポトーシス / マウス病原性 |
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| Research Abstract |
We have characterized of Legionella pneumophila hyper-toxic mutants which are intracellular growth-deficient (Toxh mutants) for infectivity and cytotoxicity to host cells. And the chromosomal loci of mini-Tn10::kan-insertion in Toxh mutants and a gene responsible for a phenotype of one of their mutants have identified. Furthermore, pathogenisity of Toxh mutants were evaluated using A/J mice, which are susceptible to replicative L. pneumophila infections.
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[Journal Article] Ciliates expel environmental Legionella-laden pellets to stockpile food.2012
Author(s)
Fuhito Hojo, Daisuke Sato, Junji Matsuo, Masaki Miyake, Shinji Nakamura, Miyuki Kunichika, Yasuhiro Hayashi, Mitsutaka Yoshida, Kaori Takahashi, Hiromu Takemura, Shigeru Kamiya and Hiroyuki Yamaguchi
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Journal Title
Appl. Environ. Microbiol.
Volume: 78
Pages: 5247-5257
DOI
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