2012 Fiscal Year Final Research Report
Integrated analyses of virulence factors from Staphylococcus aureusaiming to pursue novel pathogenic mechanisms and chemotherapy based on new concept
| Project/Area Number |
22590402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Juntendo University |
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Principal Investigator |
BABA Tadashi 順天堂大学, 医学部, 准教授 (30317458)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 黄色ブドウ球菌 / 赤血球溶解毒素 / β-ヘモリジン / ヒトケラチノサイト / アトピー性皮膚炎 / nybomycin / キノロン / gyrase |
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| Research Abstract |
On the way to pursue novel pathogenic mechanisms that can be candidates for targets of novel chemotherapy, I found ・-hemolysin, known as an erythrolytic toxin from Staphylococcus aureus, damages human keratinocytes. This result suggests that the toxin is presumably involved in atopic dermatitis that is worsened by S. aureus infection, and the finding may lead to further understanding of the disease and its therapy. I also played part in research on re-evaluation of nybomycin, that had been isolated from actinobacteria over 50 years ago, and showed that the substance specifically inhibits function of mutated bacterial DNA gyrase that was no longer inactivated by fluoroquinolones, whereas nybomycin-resistant DNA gyrase acquired fluoroquinolone susceptibility, indicating fluoroquinolones and nybomicin have mutually complementary functions. Such substance against known antibiotic was designated ‘reverse antibiotic’, being expected to open new era of antibiotic chemotherapy. It should be noted that the results described above were obtained cooperative researches with scientists who were originally out of this project.
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[Journal Article] Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence2011
Author(s)
Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, Sekimizu K
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Journal Title
PLos Pathg
Volume: 7
Pages: e1001267
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[Journal Article] Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway2010
Author(s)
Anh Tuan Vu, Tadashi Baba, Xue Chen, Tuan Anh Le, Hirokazu Kinoshita, Yang Xie, Seiji Kamijo, Keiichi Hiramatsu, Shigaku Ikeda, Hideoki Ogawa, Ko Okumura, Toshiro Takai
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Journal Title
J. allergy clin immunol
Volume: 126
Pages: 985-93
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