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2012 Fiscal Year Final Research Report

Characterization of immunotoxicological and immunopathological roles of fungal PAMPs

Research Project

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Project/Area Number 22590406
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

OHNO Naohito  東京薬科大学, 薬学部, 教授 (80152213)

Co-Investigator(Renkei-kenkyūsha) ADACHI Yoshiyuki  東京薬科大学, 薬学部, 准教授 (60222634)
MIURA Noriko  東京薬科大学, 薬学部, 講師 (60222634)
ISHIBASHI Ken-ichi  東京薬科大学, 薬学部, 助教 (60222634)
Project Period (FY) 2010 – 2012
Keywords感染免疫 / PAMPs
Research Abstract

DBA/2 is a strain, specifically higher response to fungal PAMPs, beta-glucan. In the present study, immunotoxicological and immunopathological rolesof fungal PAMPs were examined. From the results of this study, we have demonstratedthat DBA/2 mice is a highly sensitive strain to produce high level of inflammatory cytokinein vitro and in vito. In vitro study, DBA/2 mice produced significantly high level of inflammatory cytokines, such as GM-CSF, IFN-gamma, and TNF-alpha. It is highly sensitive tothe cross-linking of cytoskeleton and modulated by disrupting actin polymerization. In vivo study, producing high concentration of anti-beta-glucan antibody and induce lethal toxicity. From these findings, it is a good tool to analyze beta-glucan mediated immunotoxicological response.

  • Research Products

    (5 results)

All 2012 2011 2010 Other

All Presentation (3 results) Book (1 results) Remarks (1 results)

  • [Presentation] Disruption of actin cytoskeleton enhanced cytokine synthesis of splenocytes stimulated with beta-glucan in vitro2012

    • Author(s)
      N.Ohno、A. Shibata、K. Ishibashi、NN. Miura、 Y. Adachi
    • Organizer
      18th Congress of the International Society for Human and Animal Mycology
    • Place of Presentation
      Berlin、 Germany
    • Year and Date
      2012-06-11
  • [Presentation] Augmentation of cytokine synthesis of splenocytes stimulated with soluble ss-Glucan in vitro by inhibiting actin polymerization2011

    • Author(s)
      N. Ohno、A. Shibata、TH. Hida、 K.Ishibashi、NN. Miura、Y. Adachi
    • Organizer
      IUMS (International Union of Microbiological Societies)
    • Place of Presentation
      札幌市
    • Year and Date
      2011-09-06
  • [Presentation] Gene expression of splenocytes induced by beta-glucan SCG in DBA/2 mice2010

    • Author(s)
      TH.Hida、K. Ishibashi、NN. Miura、Y. Adachi、N. Ohno
    • Organizer
      14TH INTERNATIONAL CONGRESS OF IMMUNOLOGY
    • Place of Presentation
      神戸市
    • Year and Date
      2010-08-22
  • [Book] ssグルカンの基礎と応用-感染、抗がん、ならびに機能性食品へのssグルカンの関与-2010

    • Author(s)
      大野尚仁、安達禎之、三浦典子、石橋健一、飛田敏江、山中大輔
    • Total Pages
      283
    • Publisher
      シーエムシー
  • [Remarks]

    • URL

      http://www.toyaku.ac.jp/

URL: 

Published: 2014-08-29  

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