2012 Fiscal Year Final Research Report
Study on roles of human metapneumovirus accessory proteins in viral pathogenecity
| Project/Area Number |
22590414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
GOTOH Bin 滋賀医科大学, 医学部, 教授 (00211920)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAGAWA Yoshinori 滋賀医科大学, 医学部, 助教 (00444448)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ヒトメタニューモウイルス / アクセサリータンパク質 / 転写複製 / M2-2タンパク質 / インターフェロン / TLR7/9 / IRF7 / 形質細胞様樹状細胞 |
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| Research Abstract |
The present study has uncovered the following functions of human metapneumovirus accessory protein M2-2. Firstly, M2-2 binds to viral RNA polymerase L and negatively regulates replication and transcription of viral genome. Secondly, M2-2 potentially serves as an interferon (IFN) antagonist that inhibits alpha IFN production. This activity is independent of the inhibitory activity against genome replication and transcription, and ascribed to the blockade of Toll-like receptor 7/9-dependent signaling in plasmacytoid dendritic cells characteristic of producing a large amount of alpha IFN.
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