2012 Fiscal Year Final Research Report
Role of Rab proteins and related host factors in HIV-1 assembly
| Project/Area Number |
22590427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
MURAKAMI Tsutomu 国立感染症研究所, エイズ研究センター, 室長 (50336385)
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| Project Period (FY) |
2010 – 2012
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| Keywords | Rab 蛋白質 |
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| Research Abstract |
We hypothesized that some Rab proteins play roles in HIV-1 assembly and/or release. In the present study, we focused on Rab11, one of important regulators of recycling of cellular glycoproteins to the plasma membrane, and examined its potential roles in HIV-1 assembly. The results shown by the experiments using Rab11-kock down cells or cells that over-express Rab11 mutants suggest that Rab11 is involved in the formation of infectious virions by modulating trafficking of the HIV-1 Env glycoproteins.
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