2012 Fiscal Year Final Research Report
Analysis of the regulation of plasmacytoid dendritic cells by the rece ptors and novel molecules.
| Project/Area Number |
22590431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 免疫学 / 感染症 |
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| Research Abstract |
Plasmacytoid dendritic cells (pDCs) produce type I interferons (IFNs) in response to viral nucleic acids to exert antiviral immunity. In the presentstudy, we showed that an inhibitory major histocompatibility complex class I receptor,paired immunoglobulin-like receptor (PIR)-B, suppressed TLR9-mediated IFN-α productionby inhibiting the positive feedback mechanism of IFN-α secretion.
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Research Products
(14 results)
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[Journal Article] Runx1 deficiency in CD4 cells causes fatal utoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.2012
Author(s)
Wong WF,Kohu K,Nakamura A,Ebina M,Kikuchi T,Tazawa R,Tanaka K,Kon S,Funaki T,Sugahara-Tobinai A,Looi CY,Endo S,Funayama R,Kurokawa M,Habu S,Ishii N,Fukumoto M,Nakata K,Takai T,Satake M
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Journal Title
Journal of Immunology
Volume: 188
Pages: 5408-5420
DOI
Peer Reviewed
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[Journal Article] Differential but competitive binding of Nogo protein and class I major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells.2011
Author(s)
Matsushita H,Endo S,Kobayashi E,Sakamoto Y,Kobayashi K,Kitaguchi K,Kuroki K,Soderhall A,Maenaka K,Nakamura A,Strittmatter SM,Takai T.
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Journal Title
JournalofBiologicalChemistry
Volume: 286
Pages: 25739-25747
DOI
Peer Reviewed
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